Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-07-01
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| Series: | Gaceta Sanitaria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S021391111400288X |
| _version_ | 1828283396840751104 |
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| author | Gemma Castaño-Vinyals Nuria Aragonés Beatriz Pérez-Gómez Vicente Martín Javier Llorca Victor Moreno Jone M. Altzibar Eva Ardanaz Sílvia de Sanjosé José Juan Jiménez-Moleón Adonina Tardón Juan Alguacil Rosana Peiró Rafael Marcos-Gragera Carmen Navarro Marina Pollán Manolis Kogevinas |
| author_facet | Gemma Castaño-Vinyals Nuria Aragonés Beatriz Pérez-Gómez Vicente Martín Javier Llorca Victor Moreno Jone M. Altzibar Eva Ardanaz Sílvia de Sanjosé José Juan Jiménez-Moleón Adonina Tardón Juan Alguacil Rosana Peiró Rafael Marcos-Gragera Carmen Navarro Marina Pollán Manolis Kogevinas |
| author_sort | Gemma Castaño-Vinyals |
| collection | DOAJ |
| description | Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.
Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects.
Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain. |
| first_indexed | 2024-04-13T08:44:38Z |
| format | Article |
| id | doaj.art-ae0a366ccae94c5a9d851b09546f1336 |
| institution | Directory Open Access Journal |
| issn | 0213-9111 |
| language | English |
| last_indexed | 2024-04-13T08:44:38Z |
| publishDate | 2015-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gaceta Sanitaria |
| spelling | doaj.art-ae0a366ccae94c5a9d851b09546f13362022-12-22T02:53:45ZengElsevierGaceta Sanitaria0213-91112015-07-0129430831510.1016/j.gaceta.2014.12.003Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study designGemma Castaño-Vinyals0Nuria Aragonés1Beatriz Pérez-Gómez2Vicente Martín3Javier Llorca4Victor Moreno5Jone M. Altzibar6Eva Ardanaz7Sílvia de Sanjosé8José Juan Jiménez-Moleón9Adonina Tardón10Juan Alguacil11Rosana Peiró12Rafael Marcos-Gragera13Carmen Navarro14Marina Pollán15Manolis Kogevinas16Centre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainEnvironmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, SpainEnvironmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, SpainUniversidad de León, León, SpainUniversidad de Cantabria, Santander, SpainIDIBELL-Catalan Institute of Oncology, L’Hospitalet de Llobregat, SpainSubdirección de Salud Pública de Gipuzkoa, Donostia, SpainInstituto de Salud Pública de Navarra, Pamplona, NavarraIDIBELL-Catalan Institute of Oncology, L’Hospitalet de Llobregat, SpainInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, Granada, SpainInstituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Asturias, SpainCentro de Investigación en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Huelva, SpainFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO–Salud Pública, Valencia, SpainEpidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, SpainDepartment of Epidemiology, Murcia Regional Health Authority, Murcia, SpainEnvironmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, SpainCentre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainIntroduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.http://www.sciencedirect.com/science/article/pii/S021391111400288XCase-controlEpidemiologyColorectal cancerProstate cancerBreast cancerGastric cancerChronic lymphocytic leukemia |
| spellingShingle | Gemma Castaño-Vinyals Nuria Aragonés Beatriz Pérez-Gómez Vicente Martín Javier Llorca Victor Moreno Jone M. Altzibar Eva Ardanaz Sílvia de Sanjosé José Juan Jiménez-Moleón Adonina Tardón Juan Alguacil Rosana Peiró Rafael Marcos-Gragera Carmen Navarro Marina Pollán Manolis Kogevinas Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design Gaceta Sanitaria Case-control Epidemiology Colorectal cancer Prostate cancer Breast cancer Gastric cancer Chronic lymphocytic leukemia |
| title | Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design |
| title_full | Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design |
| title_fullStr | Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design |
| title_full_unstemmed | Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design |
| title_short | Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design |
| title_sort | population based multicase control study in common tumors in spain mcc spain rationale and study design |
| topic | Case-control Epidemiology Colorectal cancer Prostate cancer Breast cancer Gastric cancer Chronic lymphocytic leukemia |
| url | http://www.sciencedirect.com/science/article/pii/S021391111400288X |
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