Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines
A charged porous microneedle (PMN) generates the electroosmotic flow (EOF) and promotes the through‐needle transport of molecules and particles, indicating its applicability for the EOF‐based low‐invasive transdermal delivery of drugs and vaccines. The negatively charged PMN is prepared by grafting...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-01-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202100066 |
| _version_ | 1818968620314656768 |
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| author | Hiroya Abe Kaito Sato Natsumi Kimura Shinya Kusama Daisuke Inoue Kenshi Yamasaki Matsuhiko Nishizawa |
| author_facet | Hiroya Abe Kaito Sato Natsumi Kimura Shinya Kusama Daisuke Inoue Kenshi Yamasaki Matsuhiko Nishizawa |
| author_sort | Hiroya Abe |
| collection | DOAJ |
| description | A charged porous microneedle (PMN) generates the electroosmotic flow (EOF) and promotes the through‐needle transport of molecules and particles, indicating its applicability for the EOF‐based low‐invasive transdermal delivery of drugs and vaccines. The negatively charged PMN is prepared by grafting a thin film of poly (2‐acrylamido‐2‐methylpropanesulfonic acid) (PAMPS) onto the inner wall of the microchannels of the polyglycidyl methacrylate PMN. Promoted transport from anode to cathode is observed for albumin, Au nanoparticles (15, 50 nm), and silica beads (100 nm), indicating the generation of an EOF strong enough to transport these negatively charged larger size species against their electrophoretic motion. A model antigen ovalbumin (OVA) is preloaded in the PMN, and is injected to a hydrogel and a pig skin with a higher efficiency (more than 2 times) than the conventional diffusion‐based passive release. These results successfully demonstrate the novel EOF‐based effective injection of drugs and vaccines into the skin, achieved by the newly developed charged PMN. |
| first_indexed | 2024-12-20T14:07:35Z |
| format | Article |
| id | doaj.art-ae0aebc9f2e04460bd4f9e8dc34456c7 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-12-20T14:07:35Z |
| publishDate | 2022-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-ae0aebc9f2e04460bd4f9e8dc34456c72022-12-21T19:38:15ZengWiley-VCHAdvanced NanoBiomed Research2699-93072022-01-0121n/an/a10.1002/anbr.202100066Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and VaccinesHiroya Abe0Kaito Sato1Natsumi Kimura2Shinya Kusama3Daisuke Inoue4Kenshi Yamasaki5Matsuhiko Nishizawa6Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 JapanDepartment of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 JapanDepartment of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 JapanDepartment of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 JapanDepartment of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 JapanDepartment of Dermatology Graduate School of Medicine Tohoku University 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanDepartment of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 JapanA charged porous microneedle (PMN) generates the electroosmotic flow (EOF) and promotes the through‐needle transport of molecules and particles, indicating its applicability for the EOF‐based low‐invasive transdermal delivery of drugs and vaccines. The negatively charged PMN is prepared by grafting a thin film of poly (2‐acrylamido‐2‐methylpropanesulfonic acid) (PAMPS) onto the inner wall of the microchannels of the polyglycidyl methacrylate PMN. Promoted transport from anode to cathode is observed for albumin, Au nanoparticles (15, 50 nm), and silica beads (100 nm), indicating the generation of an EOF strong enough to transport these negatively charged larger size species against their electrophoretic motion. A model antigen ovalbumin (OVA) is preloaded in the PMN, and is injected to a hydrogel and a pig skin with a higher efficiency (more than 2 times) than the conventional diffusion‐based passive release. These results successfully demonstrate the novel EOF‐based effective injection of drugs and vaccines into the skin, achieved by the newly developed charged PMN.https://doi.org/10.1002/anbr.202100066electroosmosisporous microneedlestransdermal drug deliveriesvaccines |
| spellingShingle | Hiroya Abe Kaito Sato Natsumi Kimura Shinya Kusama Daisuke Inoue Kenshi Yamasaki Matsuhiko Nishizawa Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines Advanced NanoBiomed Research electroosmosis porous microneedles transdermal drug deliveries vaccines |
| title | Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines |
| title_full | Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines |
| title_fullStr | Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines |
| title_full_unstemmed | Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines |
| title_short | Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines |
| title_sort | porous microneedle patch for electroosmosis promoted transdermal delivery of drugs and vaccines |
| topic | electroosmosis porous microneedles transdermal drug deliveries vaccines |
| url | https://doi.org/10.1002/anbr.202100066 |
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