Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10190 |
| _version_ | 1819035708883468288 |
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| author | Chia-Ti Tsai Chia-Shan Hsieh Sheng-Nan Chang Eric Y. Chuang Kwo-Chang Ueng Chin-Feng Tsai Tsung-Hsien Lin Cho-Kai Wu Jen-Kuang Lee Lian-Yu Lin Yi-Chih Wang Chih-Chieh Yu Ling-Ping Lai Chuen-Den Tseng Juey-Jen Hwang Fu-Tien Chiang Jiunn-Lee Lin |
| author_facet | Chia-Ti Tsai Chia-Shan Hsieh Sheng-Nan Chang Eric Y. Chuang Kwo-Chang Ueng Chin-Feng Tsai Tsung-Hsien Lin Cho-Kai Wu Jen-Kuang Lee Lian-Yu Lin Yi-Chih Wang Chih-Chieh Yu Ling-Ping Lai Chuen-Den Tseng Juey-Jen Hwang Fu-Tien Chiang Jiunn-Lee Lin |
| author_sort | Chia-Ti Tsai |
| collection | DOAJ |
| description | Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart electrophysiological function using cultured myocytes and zebrafish. |
| first_indexed | 2024-12-21T07:53:56Z |
| format | Article |
| id | doaj.art-ae0b2f3bbf4f455ea88fd5d422ffefc4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:53:56Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ae0b2f3bbf4f455ea88fd5d422ffefc42022-12-21T19:11:01ZengNature PortfolioNature Communications2041-17232016-02-01711910.1038/ncomms10190Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillationChia-Ti Tsai0Chia-Shan Hsieh1Sheng-Nan Chang2Eric Y. Chuang3Kwo-Chang Ueng4Chin-Feng Tsai5Tsung-Hsien Lin6Cho-Kai Wu7Jen-Kuang Lee8Lian-Yu Lin9Yi-Chih Wang10Chih-Chieh Yu11Ling-Ping Lai12Chuen-Den Tseng13Juey-Jen Hwang14Fu-Tien Chiang15Jiunn-Lee Lin16Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDepartment of Life Science, Genome and Systems Biology Degree Program, National Taiwan UniversityGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan UniversityDepartment of Life Science, Genome and Systems Biology Degree Program, National Taiwan UniversitySchool of Medicine, Chung Shan Medical UniversitySchool of Medicine, Chung Shan Medical UniversityDivision of Cardiology, Department of Internal Medicine, Kaohsiung Medical University and Chung-Ho Memorial HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalTsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart electrophysiological function using cultured myocytes and zebrafish.https://doi.org/10.1038/ncomms10190 |
| spellingShingle | Chia-Ti Tsai Chia-Shan Hsieh Sheng-Nan Chang Eric Y. Chuang Kwo-Chang Ueng Chin-Feng Tsai Tsung-Hsien Lin Cho-Kai Wu Jen-Kuang Lee Lian-Yu Lin Yi-Chih Wang Chih-Chieh Yu Ling-Ping Lai Chuen-Den Tseng Juey-Jen Hwang Fu-Tien Chiang Jiunn-Lee Lin Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation Nature Communications |
| title | Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation |
| title_full | Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation |
| title_fullStr | Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation |
| title_full_unstemmed | Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation |
| title_short | Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation |
| title_sort | genome wide screening identifies a kcnip1 copy number variant as a genetic predictor for atrial fibrillation |
| url | https://doi.org/10.1038/ncomms10190 |
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