Skin Regenerative and Anti-Cancer Actions of Copper Peptides
Topical remedies capable of protecting skin from damage and supporting its regeneration can improve skin’s health as well as its appearance. Small copper peptides have an excellent safety record and are widely used in cosmetic products. The most studied copper peptide is GHK-Cu (glycyl-L-h...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-04-01
|
| Series: | Cosmetics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-9284/5/2/29 |
| _version_ | 1819210077991600128 |
|---|---|
| author | Loren Pickart Anna Margolina |
| author_facet | Loren Pickart Anna Margolina |
| author_sort | Loren Pickart |
| collection | DOAJ |
| description | Topical remedies capable of protecting skin from damage and supporting its regeneration can improve skin’s health as well as its appearance. Small copper peptides have an excellent safety record and are widely used in cosmetic products. The most studied copper peptide is GHK-Cu (glycyl-L-histidyl-L-lysine), a small copper-binding peptide, naturally present in human plasma. Since its discovery in 1973, in vivo and in vitro studies have shown that GHK-Cu possesses a wealth of health-positive actions including improving wound contraction and epithelization, and increasing the production of growth factors and activity of antioxidant enzymes. Recently, gene expression profiling shed new light on diverse biological actions of GHK-Cu. The present paper discusses evidence of GHK-Cu and other small copper peptides possessing potent anti-cancer properties. |
| first_indexed | 2024-12-23T06:05:27Z |
| format | Article |
| id | doaj.art-ae0d2b6df6844df4ab129fbab083a067 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-12-23T06:05:27Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-ae0d2b6df6844df4ab129fbab083a0672022-12-21T17:57:35ZengMDPI AGCosmetics2079-92842018-04-01522910.3390/cosmetics5020029cosmetics5020029Skin Regenerative and Anti-Cancer Actions of Copper PeptidesLoren Pickart0Anna Margolina1Skin Biology, 4122 Factoria Boulevard SE, Suite Number 200, Bellevue, WA 98006, USASkin Biology, 4122 Factoria Boulevard SE, Suite Number 200, Bellevue, WA 98006, USATopical remedies capable of protecting skin from damage and supporting its regeneration can improve skin’s health as well as its appearance. Small copper peptides have an excellent safety record and are widely used in cosmetic products. The most studied copper peptide is GHK-Cu (glycyl-L-histidyl-L-lysine), a small copper-binding peptide, naturally present in human plasma. Since its discovery in 1973, in vivo and in vitro studies have shown that GHK-Cu possesses a wealth of health-positive actions including improving wound contraction and epithelization, and increasing the production of growth factors and activity of antioxidant enzymes. Recently, gene expression profiling shed new light on diverse biological actions of GHK-Cu. The present paper discusses evidence of GHK-Cu and other small copper peptides possessing potent anti-cancer properties.http://www.mdpi.com/2079-9284/5/2/29GHK-Cucopper peptidesskin cancergene profilinggene expressionregeneration |
| spellingShingle | Loren Pickart Anna Margolina Skin Regenerative and Anti-Cancer Actions of Copper Peptides Cosmetics GHK-Cu copper peptides skin cancer gene profiling gene expression regeneration |
| title | Skin Regenerative and Anti-Cancer Actions of Copper Peptides |
| title_full | Skin Regenerative and Anti-Cancer Actions of Copper Peptides |
| title_fullStr | Skin Regenerative and Anti-Cancer Actions of Copper Peptides |
| title_full_unstemmed | Skin Regenerative and Anti-Cancer Actions of Copper Peptides |
| title_short | Skin Regenerative and Anti-Cancer Actions of Copper Peptides |
| title_sort | skin regenerative and anti cancer actions of copper peptides |
| topic | GHK-Cu copper peptides skin cancer gene profiling gene expression regeneration |
| url | http://www.mdpi.com/2079-9284/5/2/29 |
| work_keys_str_mv | AT lorenpickart skinregenerativeandanticanceractionsofcopperpeptides AT annamargolina skinregenerativeandanticanceractionsofcopperpeptides |