Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution
The high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life. These structural characteristics allow the T-loop to adopt a peculiar intraloop conformation able to interact specifically with other c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/2/140 |
| _version_ | 1797408600150245376 |
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| author | Martine Roovers Louis Droogmans Henri Grosjean |
| author_facet | Martine Roovers Louis Droogmans Henri Grosjean |
| author_sort | Martine Roovers |
| collection | DOAJ |
| description | The high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life. These structural characteristics allow the T-loop to adopt a peculiar intraloop conformation able to interact specifically with other conserved residues of the D-loop, which ultimately folds the mature tRNA in a unique functional canonical L-shaped architecture. Paradoxically, despite the high conservation of modified nucleotides in the T-loop, enzymes catalyzing their formation depend mostly on the considered organism, attesting for an independent but convergent evolution of the post-transcriptional modification processes. The driving force behind this is the preservation of a native conformation of the tRNA elbow that underlies the various interactions of tRNA molecules with different cellular components. |
| first_indexed | 2024-03-09T04:01:45Z |
| format | Article |
| id | doaj.art-ae0e47fb40c54eb087a42ddba7a2e86d |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T04:01:45Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ae0e47fb40c54eb087a42ddba7a2e86d2023-12-03T14:13:15ZengMDPI AGGenes2073-44252021-01-0112214010.3390/genes12020140Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent EvolutionMartine Roovers0Louis Droogmans1Henri Grosjean2Labiris, Avenue E. Gryson 1, 1070 Bruxelles, BelgiumLaboratoire de Chimie Biologique, Université Libre de Bruxelles (ULB), Labiris, Avenue E. Gryson 1, 1070 Bruxelles, BelgiumLaboratoire de Chimie Biologique, Université Libre de Bruxelles (ULB), Labiris, Avenue E. Gryson 1, 1070 Bruxelles, BelgiumThe high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life. These structural characteristics allow the T-loop to adopt a peculiar intraloop conformation able to interact specifically with other conserved residues of the D-loop, which ultimately folds the mature tRNA in a unique functional canonical L-shaped architecture. Paradoxically, despite the high conservation of modified nucleotides in the T-loop, enzymes catalyzing their formation depend mostly on the considered organism, attesting for an independent but convergent evolution of the post-transcriptional modification processes. The driving force behind this is the preservation of a native conformation of the tRNA elbow that underlies the various interactions of tRNA molecules with different cellular components.https://www.mdpi.com/2073-4425/12/2/140tRNAT-loopnucleotide modificationsevolution |
| spellingShingle | Martine Roovers Louis Droogmans Henri Grosjean Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution Genes tRNA T-loop nucleotide modifications evolution |
| title | Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution |
| title_full | Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution |
| title_fullStr | Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution |
| title_full_unstemmed | Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution |
| title_short | Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution |
| title_sort | post transcriptional modifications of conserved nucleotides in the t loop of trna a tale of functional convergent evolution |
| topic | tRNA T-loop nucleotide modifications evolution |
| url | https://www.mdpi.com/2073-4425/12/2/140 |
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