Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease
Abstract Quantitative body composition affects the prognosis of patients with Mycobacterium avium complex pulmonary disease (MAC-PD). However, whether the qualitative body composition obtained indirectly through computed tomography (CT) affects their prognosis is debatable. We retrospectively analyz...
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| Format: | Article |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40984-y |
| _version_ | 1797452606359994368 |
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| author | Eunki Chung Youngmok Park Song Yee Kim Moo Suk Park Young Sam Kim Hye-Jeong Lee Young Ae Kang |
| author_facet | Eunki Chung Youngmok Park Song Yee Kim Moo Suk Park Young Sam Kim Hye-Jeong Lee Young Ae Kang |
| author_sort | Eunki Chung |
| collection | DOAJ |
| description | Abstract Quantitative body composition affects the prognosis of patients with Mycobacterium avium complex pulmonary disease (MAC-PD). However, whether the qualitative body composition obtained indirectly through computed tomography (CT) affects their prognosis is debatable. We retrospectively analyzed patients with MAC-PD who underwent non-contrast CT at MAC-PD diagnosis. The cross-sectional area of the erector spinae muscle (ESM area), the Hounsfield unit of the erector spinae muscle (ESM HU), and the cross-sectional area of subcutaneous fat (SQF area) were measured at the level of the first lumbar vertebra. Myosteatosis were defined below the median value of ESM HU for each sex. Of 377 patients, 45 (11.9%) died during the follow-up. Patients who died were older and had a lower ratio of females (33.3%). In body compositions, SQF area and ESM HU were lower in the patients who died. In multivariable analysis, a low ESM HU was associated with increased mortality (ESM HU adjusted hazard ratio [aHR] 0.95, 95% confidence interval [CI] 0.93–0.97) through body composition. SQF area revealed protective effects in MAC-PD patients with body mass index ≥ 18.5 kg/m2 (aHR 0.98, 95% CI 0.95–1.00). In conclusion, the decrease in ESM HU, which indirectly reflects myosteatosis, is associated with mortality in patients with MAC-PD. |
| first_indexed | 2024-03-09T15:11:04Z |
| format | Article |
| id | doaj.art-ae0e5b3ad10f4f9bb4675a17202e4995 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:11:04Z |
| publishDate | 2023-08-01 |
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| series | Scientific Reports |
| spelling | doaj.art-ae0e5b3ad10f4f9bb4675a17202e49952023-11-26T13:22:33ZengNature PortfolioScientific Reports2045-23222023-08-011311910.1038/s41598-023-40984-yMyosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary diseaseEunki Chung0Youngmok Park1Song Yee Kim2Moo Suk Park3Young Sam Kim4Hye-Jeong Lee5Young Ae Kang6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of MedicineDepartment of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of MedicineAbstract Quantitative body composition affects the prognosis of patients with Mycobacterium avium complex pulmonary disease (MAC-PD). However, whether the qualitative body composition obtained indirectly through computed tomography (CT) affects their prognosis is debatable. We retrospectively analyzed patients with MAC-PD who underwent non-contrast CT at MAC-PD diagnosis. The cross-sectional area of the erector spinae muscle (ESM area), the Hounsfield unit of the erector spinae muscle (ESM HU), and the cross-sectional area of subcutaneous fat (SQF area) were measured at the level of the first lumbar vertebra. Myosteatosis were defined below the median value of ESM HU for each sex. Of 377 patients, 45 (11.9%) died during the follow-up. Patients who died were older and had a lower ratio of females (33.3%). In body compositions, SQF area and ESM HU were lower in the patients who died. In multivariable analysis, a low ESM HU was associated with increased mortality (ESM HU adjusted hazard ratio [aHR] 0.95, 95% confidence interval [CI] 0.93–0.97) through body composition. SQF area revealed protective effects in MAC-PD patients with body mass index ≥ 18.5 kg/m2 (aHR 0.98, 95% CI 0.95–1.00). In conclusion, the decrease in ESM HU, which indirectly reflects myosteatosis, is associated with mortality in patients with MAC-PD.https://doi.org/10.1038/s41598-023-40984-y |
| spellingShingle | Eunki Chung Youngmok Park Song Yee Kim Moo Suk Park Young Sam Kim Hye-Jeong Lee Young Ae Kang Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease Scientific Reports |
| title | Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease |
| title_full | Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease |
| title_fullStr | Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease |
| title_full_unstemmed | Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease |
| title_short | Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease |
| title_sort | myosteatosis as a prognostic factor of mycobacterium avium complex pulmonary disease |
| url | https://doi.org/10.1038/s41598-023-40984-y |
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