| Summary: | Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (<b>1</b>–<b>7</b>), along with the known analogue cladosporiumin D (<b>8</b>), were obtained from the extract of the deep-sea-derived fungus <i>Lecanicillium fusisporum</i> GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds <b>1</b>, <b>2</b>, <b>5</b>–<b>7</b> exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC<sub>50</sub> values range of 18.49–30.19 μM.
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