New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i>
Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (<b>1</b>–<b>7</b>), along with the known analogue cladosporiumin D (<b>8</b>), were obtained from the extract of the deep-sea-derived fungus <i>Lecanicillium fusisporum</i>...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/4/255 |
| _version_ | 1827619667870482432 |
|---|---|
| author | Xinya Xu Yanhui Tan Chenghai Gao Kai Liu Zhenzhou Tang Chunju Lu Haiyan Li Xiaoyong Zhang Yonghong Liu |
| author_facet | Xinya Xu Yanhui Tan Chenghai Gao Kai Liu Zhenzhou Tang Chunju Lu Haiyan Li Xiaoyong Zhang Yonghong Liu |
| author_sort | Xinya Xu |
| collection | DOAJ |
| description | Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (<b>1</b>–<b>7</b>), along with the known analogue cladosporiumin D (<b>8</b>), were obtained from the extract of the deep-sea-derived fungus <i>Lecanicillium fusisporum</i> GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds <b>1</b>, <b>2</b>, <b>5</b>–<b>7</b> exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC<sub>50</sub> values range of 18.49–30.19 μM. |
| first_indexed | 2024-03-09T10:32:20Z |
| format | Article |
| id | doaj.art-ae116df4ecc248249e454ce54ba6122b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T10:32:20Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ae116df4ecc248249e454ce54ba6122b2023-12-01T21:10:56ZengMDPI AGMarine Drugs1660-33972022-04-0120425510.3390/md20040255New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i>Xinya Xu0Yanhui Tan1Chenghai Gao2Kai Liu3Zhenzhou Tang4Chunju Lu5Haiyan Li6Xiaoyong Zhang7Yonghong Liu8Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Marine Sciences, South China Agricultural University, Guangzhou 510642, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaSeven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (<b>1</b>–<b>7</b>), along with the known analogue cladosporiumin D (<b>8</b>), were obtained from the extract of the deep-sea-derived fungus <i>Lecanicillium fusisporum</i> GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds <b>1</b>, <b>2</b>, <b>5</b>–<b>7</b> exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC<sub>50</sub> values range of 18.49–30.19 μM.https://www.mdpi.com/1660-3397/20/4/255tetramic acid derivativesdeep-sea fungusclavipitacae<i>Lecanicillium fusisporum</i>anti-inflammatory activity |
| spellingShingle | Xinya Xu Yanhui Tan Chenghai Gao Kai Liu Zhenzhou Tang Chunju Lu Haiyan Li Xiaoyong Zhang Yonghong Liu New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i> Marine Drugs tetramic acid derivatives deep-sea fungus clavipitacae <i>Lecanicillium fusisporum</i> anti-inflammatory activity |
| title | New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i> |
| title_full | New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i> |
| title_fullStr | New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i> |
| title_full_unstemmed | New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i> |
| title_short | New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i> |
| title_sort | new 3 acyl tetramic acid derivatives from the deep sea derived fungus i lecanicillium fusisporum i |
| topic | tetramic acid derivatives deep-sea fungus clavipitacae <i>Lecanicillium fusisporum</i> anti-inflammatory activity |
| url | https://www.mdpi.com/1660-3397/20/4/255 |
| work_keys_str_mv | AT xinyaxu new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT yanhuitan new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT chenghaigao new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT kailiu new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT zhenzhoutang new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT chunjulu new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT haiyanli new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT xiaoyongzhang new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi AT yonghongliu new3acyltetramicacidderivativesfromthedeepseaderivedfungusilecanicilliumfusisporumi |