<i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats
The development of many chronic diseases is associated with an excess of free radicals leading to harmful oxidative stress. Certain probiotic strains have been shown to have antioxidant and anti-aging properties and are an important resource for development of microbial antioxidants. The present stu...
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/11/2146 |
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| author | Porntipha Vitheejongjaroen Anongnard Kasorn Narathip Puttarat Fabien Loison Malai Taweechotipatr |
| author_facet | Porntipha Vitheejongjaroen Anongnard Kasorn Narathip Puttarat Fabien Loison Malai Taweechotipatr |
| author_sort | Porntipha Vitheejongjaroen |
| collection | DOAJ |
| description | The development of many chronic diseases is associated with an excess of free radicals leading to harmful oxidative stress. Certain probiotic strains have been shown to have antioxidant and anti-aging properties and are an important resource for development of microbial antioxidants. The present study aimed to explore the protection offered by <i>Bifidobacterium animalis</i> strain MSMC83 in a model of oxidative stress induced by D-galactose (D-gal). Male Sprague Dawley rats were randomly allocated to four groups: a control group injected with saline, a group injected subcutaneously with D-galactose, a probiotic group injected with D-galactose and administered <i>B. animalis</i> MSMC83 (10<sup>9</sup> CFU/mL) via daily oral gavage, and an ascorbic acid group. The probiotics significantly increased the superoxide dismutase, catalase, and glutathione peroxidase and significantly decreased the malondialdehyde in the plasma and livers of D-galactose-treated rats. Moreover, tumor necrosis factor-alpha level in the liver was significantly decreased. Furthermore, the treatment with <i>B. animalis</i> MSMC83 restored the microbiota diversity after D-galactose injection. Therefore, our results supported a beneficial role of <i>B. animalis</i> MSMC83 in alleviating oxidative stress through the increased expression of antioxidant enzymes and reduction of pro-inflammatory cytokines in rats. Our study suggests that <i>B. animalis</i> MSMC83 may be part of a healthy diet to prevent oxidative stress-associated diseases. |
| first_indexed | 2024-03-09T19:19:20Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T19:19:20Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ae12c58e322d4d048bb5cf12377700762023-11-24T03:29:58ZengMDPI AGAntioxidants2076-39212022-10-011111214610.3390/antiox11112146<i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced RatsPorntipha Vitheejongjaroen0Anongnard Kasorn1Narathip Puttarat2Fabien Loison3Malai Taweechotipatr4Center of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandDepartment of Biomedical Science, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandCenter of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandCenter of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandThe development of many chronic diseases is associated with an excess of free radicals leading to harmful oxidative stress. Certain probiotic strains have been shown to have antioxidant and anti-aging properties and are an important resource for development of microbial antioxidants. The present study aimed to explore the protection offered by <i>Bifidobacterium animalis</i> strain MSMC83 in a model of oxidative stress induced by D-galactose (D-gal). Male Sprague Dawley rats were randomly allocated to four groups: a control group injected with saline, a group injected subcutaneously with D-galactose, a probiotic group injected with D-galactose and administered <i>B. animalis</i> MSMC83 (10<sup>9</sup> CFU/mL) via daily oral gavage, and an ascorbic acid group. The probiotics significantly increased the superoxide dismutase, catalase, and glutathione peroxidase and significantly decreased the malondialdehyde in the plasma and livers of D-galactose-treated rats. Moreover, tumor necrosis factor-alpha level in the liver was significantly decreased. Furthermore, the treatment with <i>B. animalis</i> MSMC83 restored the microbiota diversity after D-galactose injection. Therefore, our results supported a beneficial role of <i>B. animalis</i> MSMC83 in alleviating oxidative stress through the increased expression of antioxidant enzymes and reduction of pro-inflammatory cytokines in rats. Our study suggests that <i>B. animalis</i> MSMC83 may be part of a healthy diet to prevent oxidative stress-associated diseases.https://www.mdpi.com/2076-3921/11/11/2146probiotics<i>Bifidobacterium</i>oxidative stressinflammationmicrobiota |
| spellingShingle | Porntipha Vitheejongjaroen Anongnard Kasorn Narathip Puttarat Fabien Loison Malai Taweechotipatr <i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats Antioxidants probiotics <i>Bifidobacterium</i> oxidative stress inflammation microbiota |
| title | <i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats |
| title_full | <i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats |
| title_fullStr | <i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats |
| title_full_unstemmed | <i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats |
| title_short | <i>Bifidobacterium animalis</i> MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats |
| title_sort | i bifidobacterium animalis i msmc83 improves oxidative stress and gut microbiota in d galactose induced rats |
| topic | probiotics <i>Bifidobacterium</i> oxidative stress inflammation microbiota |
| url | https://www.mdpi.com/2076-3921/11/11/2146 |
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