Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension
Purpose We investigated continuous positive airway pressure (CPAP) adherence and its association with the blood pressure (BP) and pulse rate changes in patients with obstructive sleep apnoea syndrome (OSAS) and hypertension. Materials and methods In a single-blind trial, patients were randomly assig...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-07-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2021.1922267 |
| _version_ | 1827817847908204544 |
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| author | Jia-Hui Xia Yuan-Yuan Kang Yi-Bang Cheng Qi-Fang Huang Ting-Yan Xu Yan Li Ji-Guang Wang |
| author_facet | Jia-Hui Xia Yuan-Yuan Kang Yi-Bang Cheng Qi-Fang Huang Ting-Yan Xu Yan Li Ji-Guang Wang |
| author_sort | Jia-Hui Xia |
| collection | DOAJ |
| description | Purpose We investigated continuous positive airway pressure (CPAP) adherence and its association with the blood pressure (BP) and pulse rate changes in patients with obstructive sleep apnoea syndrome (OSAS) and hypertension. Materials and methods In a single-blind trial, patients were randomly assigned to CPAP or sham CPAP treatment for 3 months. We performed clinic, ambulatory and home BP measurements at baseline and during follow-up. CPAP adherence was assessed as the CPAP frequency per week and time per night. Non-adherence was defined as a CPAP use for <5 days/week or <4 h/night. Results In the CPAP (n = 26) and sham CPAP groups (n = 21), the CPAP frequency was 5.5 and 4.8 days/week (p = 0.17), respectively, and the CPAP time was 5.0 and 4.1 h/night (p = 0.03), respectively. The corresponding prevalence of non-adherence was 46.2% and 66.7% (p = 0.16), respectively. The CPAP frequency but not time tended to be associated with the changes in BP and pulse rate at 3 months of follow-up, especially home systolic/diastolic BP in the CPAP group (3.2/1.3 mmHg greater reductions per 1 day increment, p ≤ 0.01). Adherent, compared with non-adherent patients, had greater reductions in BP or pulse rate at 3 months of follow-up. In the CPAP and sham CPAP groups combined, statistical significance was achieved for the adjusted between adherence and non-adherence differences in home systolic/diastolic BP (–5.0/–3.8 mmHg) and 24-h, daytime and night-time ambulatory pulse rate (–6.2, −7.8 and −4.4 beats/min, respectively, p ≤ 0.04). Conclusion CPAP adherence was associated with the BP lowering and pulse rate slowing effects, especially the CPAP frequency. |
| first_indexed | 2024-03-12T00:39:24Z |
| format | Article |
| id | doaj.art-ae142f824395473da344fca7c9d7080e |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:24Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-ae142f824395473da344fca7c9d7080e2023-09-15T08:45:24ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992021-07-0130425025710.1080/08037051.2021.19222671922267Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertensionJia-Hui Xia0Yuan-Yuan Kang1Yi-Bang Cheng2Qi-Fang Huang3Ting-Yan Xu4Yan Li5Ji-Guang Wang6Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of MedicinePurpose We investigated continuous positive airway pressure (CPAP) adherence and its association with the blood pressure (BP) and pulse rate changes in patients with obstructive sleep apnoea syndrome (OSAS) and hypertension. Materials and methods In a single-blind trial, patients were randomly assigned to CPAP or sham CPAP treatment for 3 months. We performed clinic, ambulatory and home BP measurements at baseline and during follow-up. CPAP adherence was assessed as the CPAP frequency per week and time per night. Non-adherence was defined as a CPAP use for <5 days/week or <4 h/night. Results In the CPAP (n = 26) and sham CPAP groups (n = 21), the CPAP frequency was 5.5 and 4.8 days/week (p = 0.17), respectively, and the CPAP time was 5.0 and 4.1 h/night (p = 0.03), respectively. The corresponding prevalence of non-adherence was 46.2% and 66.7% (p = 0.16), respectively. The CPAP frequency but not time tended to be associated with the changes in BP and pulse rate at 3 months of follow-up, especially home systolic/diastolic BP in the CPAP group (3.2/1.3 mmHg greater reductions per 1 day increment, p ≤ 0.01). Adherent, compared with non-adherent patients, had greater reductions in BP or pulse rate at 3 months of follow-up. In the CPAP and sham CPAP groups combined, statistical significance was achieved for the adjusted between adherence and non-adherence differences in home systolic/diastolic BP (–5.0/–3.8 mmHg) and 24-h, daytime and night-time ambulatory pulse rate (–6.2, −7.8 and −4.4 beats/min, respectively, p ≤ 0.04). Conclusion CPAP adherence was associated with the BP lowering and pulse rate slowing effects, especially the CPAP frequency.http://dx.doi.org/10.1080/08037051.2021.1922267obstructive sleep apnoea syndromenocturnal hypertensioncontinuous positive airway pressureadherenceblood pressurepulse rate |
| spellingShingle | Jia-Hui Xia Yuan-Yuan Kang Yi-Bang Cheng Qi-Fang Huang Ting-Yan Xu Yan Li Ji-Guang Wang Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension Blood Pressure obstructive sleep apnoea syndrome nocturnal hypertension continuous positive airway pressure adherence blood pressure pulse rate |
| title | Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension |
| title_full | Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension |
| title_fullStr | Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension |
| title_full_unstemmed | Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension |
| title_short | Continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension |
| title_sort | continuous positive airway pressure adherence and blood pressure lowering in patients with obstructive sleep apnoea syndrome and nocturnal hypertension |
| topic | obstructive sleep apnoea syndrome nocturnal hypertension continuous positive airway pressure adherence blood pressure pulse rate |
| url | http://dx.doi.org/10.1080/08037051.2021.1922267 |
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