A brief history of taxol
Traditional application of plant in folk medicine is a base for discovery of new active chemical substances. In the second half of 20th century, significant antitumor activity of extract from bark of the Yew tree was recognized. The compound that was responsible for this kind of properties has calle...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Poznan University of Medical Sciences
2014-03-01
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| Series: | Journal of Medical Science |
| Subjects: | |
| Online Access: | https://jms.ump.edu.pl/index.php/JMS/article/view/43 |
| _version_ | 1818603019490557952 |
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| author | Justyna Żwawiak Lucjusz Zaprutko |
| author_facet | Justyna Żwawiak Lucjusz Zaprutko |
| author_sort | Justyna Żwawiak |
| collection | DOAJ |
| description | Traditional application of plant in folk medicine is a base for discovery of new active chemical substances. In the second half of 20th century, significant antitumor activity of extract from bark of the Yew tree was recognized. The compound that was responsible for this kind of properties has called taxol and had structure of diterpene with acyl groups. Low availability forced researchers to find different ways of taxol gaining. In the further years, many synthetic and semi-synthetic methods were developed. Nowadays, biotechnological methods with use of cell suspension cultures are introduced. |
| first_indexed | 2024-12-16T13:16:31Z |
| format | Article |
| id | doaj.art-ae15615052a24b30b891bafc6f1116fc |
| institution | Directory Open Access Journal |
| issn | 2353-9798 2353-9801 |
| language | English |
| last_indexed | 2024-12-16T13:16:31Z |
| publishDate | 2014-03-01 |
| publisher | Poznan University of Medical Sciences |
| record_format | Article |
| series | Journal of Medical Science |
| spelling | doaj.art-ae15615052a24b30b891bafc6f1116fc2022-12-21T22:30:28ZengPoznan University of Medical SciencesJournal of Medical Science2353-97982353-98012014-03-0183110.20883/medical.e43A brief history of taxolJustyna Żwawiak0Lucjusz Zaprutko1Chair and Department of Organic Chemistry, Poznan University of Medical Sciences, PolandChair and Department of Organic Chemistry, Poznan University of Medical Sciences, PolandTraditional application of plant in folk medicine is a base for discovery of new active chemical substances. In the second half of 20th century, significant antitumor activity of extract from bark of the Yew tree was recognized. The compound that was responsible for this kind of properties has called taxol and had structure of diterpene with acyl groups. Low availability forced researchers to find different ways of taxol gaining. In the further years, many synthetic and semi-synthetic methods were developed. Nowadays, biotechnological methods with use of cell suspension cultures are introduced.https://jms.ump.edu.pl/index.php/JMS/article/view/43cancertaxolchemotherapy |
| spellingShingle | Justyna Żwawiak Lucjusz Zaprutko A brief history of taxol Journal of Medical Science cancer taxol chemotherapy |
| title | A brief history of taxol |
| title_full | A brief history of taxol |
| title_fullStr | A brief history of taxol |
| title_full_unstemmed | A brief history of taxol |
| title_short | A brief history of taxol |
| title_sort | a brief history of taxol |
| topic | cancer taxol chemotherapy |
| url | https://jms.ump.edu.pl/index.php/JMS/article/view/43 |
| work_keys_str_mv | AT justynazwawiak abriefhistoryoftaxol AT lucjuszzaprutko abriefhistoryoftaxol |