Dual Role of Toll-like Receptors in Human and Experimental Asthma Models
Asthma is a chronic airway inflammatory disease that is influenced by the interplay between genetic factors and exposure to environmental allergens, microbes, or microbial products where toll-like receptors (TLRs) play a pivotal role. TLRs recognize a wide range of microbial or endogenous molecules...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.01027/full |
| _version_ | 1818546789231362048 |
|---|---|
| author | Amin Zakeri Amin Zakeri Momtchilo Russo |
| author_facet | Amin Zakeri Amin Zakeri Momtchilo Russo |
| author_sort | Amin Zakeri |
| collection | DOAJ |
| description | Asthma is a chronic airway inflammatory disease that is influenced by the interplay between genetic factors and exposure to environmental allergens, microbes, or microbial products where toll-like receptors (TLRs) play a pivotal role. TLRs recognize a wide range of microbial or endogenous molecules as well as airborne environmental allergens and act as adjuvants that influence positively or negatively allergic sensitization. TLRs are qualitatively and differentially expressed on hematopoietic and non-hematopoietic stromal or structural airway cells that when activated by TLRs agonists exert an immune-modulatory role in asthma development. Therefore, understanding mechanisms and pathways by which TLRs orchestrate asthma outcomes may offer new strategies to control the disease. Here, we aim to review and critically discuss the role of TLRs in human asthma and murine models of allergic airway inflammation, highlighting the complexity of TLRs function in development, exacerbation, or control of airway allergic inflammation. |
| first_indexed | 2024-12-12T07:57:55Z |
| format | Article |
| id | doaj.art-ae158ac1d4bb47faabfca234f5ac2d2f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T07:57:55Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ae158ac1d4bb47faabfca234f5ac2d2f2022-12-22T00:32:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01027340400Dual Role of Toll-like Receptors in Human and Experimental Asthma ModelsAmin Zakeri0Amin Zakeri1Momtchilo Russo2Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, DenmarkDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, BrazilAsthma is a chronic airway inflammatory disease that is influenced by the interplay between genetic factors and exposure to environmental allergens, microbes, or microbial products where toll-like receptors (TLRs) play a pivotal role. TLRs recognize a wide range of microbial or endogenous molecules as well as airborne environmental allergens and act as adjuvants that influence positively or negatively allergic sensitization. TLRs are qualitatively and differentially expressed on hematopoietic and non-hematopoietic stromal or structural airway cells that when activated by TLRs agonists exert an immune-modulatory role in asthma development. Therefore, understanding mechanisms and pathways by which TLRs orchestrate asthma outcomes may offer new strategies to control the disease. Here, we aim to review and critically discuss the role of TLRs in human asthma and murine models of allergic airway inflammation, highlighting the complexity of TLRs function in development, exacerbation, or control of airway allergic inflammation.http://journal.frontiersin.org/article/10.3389/fimmu.2018.01027/fullasthmaasthma modelstoll-like receptorsbacterial lipopolysaccharideTh2/Th1/Th17 cells |
| spellingShingle | Amin Zakeri Amin Zakeri Momtchilo Russo Dual Role of Toll-like Receptors in Human and Experimental Asthma Models Frontiers in Immunology asthma asthma models toll-like receptors bacterial lipopolysaccharide Th2/Th1/Th17 cells |
| title | Dual Role of Toll-like Receptors in Human and Experimental Asthma Models |
| title_full | Dual Role of Toll-like Receptors in Human and Experimental Asthma Models |
| title_fullStr | Dual Role of Toll-like Receptors in Human and Experimental Asthma Models |
| title_full_unstemmed | Dual Role of Toll-like Receptors in Human and Experimental Asthma Models |
| title_short | Dual Role of Toll-like Receptors in Human and Experimental Asthma Models |
| title_sort | dual role of toll like receptors in human and experimental asthma models |
| topic | asthma asthma models toll-like receptors bacterial lipopolysaccharide Th2/Th1/Th17 cells |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.01027/full |
| work_keys_str_mv | AT aminzakeri dualroleoftolllikereceptorsinhumanandexperimentalasthmamodels AT aminzakeri dualroleoftolllikereceptorsinhumanandexperimentalasthmamodels AT momtchilorusso dualroleoftolllikereceptorsinhumanandexperimentalasthmamodels |