Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study
Introduction: Acute Coronary Syndrome (ACS) is a term that encompasses various clinical presentations such as ST-Segment Elevation Myocardial Infarction (STEMI), Non STEMI (NSTEMI), or unstable angina. Neutrophil Gelatinase-associated Lipocalin (NGAL), also known as lipocalin-2, belongs to the lipoc...
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JCDR Research and Publications Private Limited
2024-04-01
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| Online Access: | https://www.jcdr.net/articles/PDF/19318/66093_CE[Ra1]_F(IS)_QC(SD_RDW_IS)_PF1(RI_DK_OM)_PFA(RI_KM)_PN(KM).pdf |
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| author | Sunanda Dalai Nirupama Devi Jhulana Kumar Jena Jyoti Prakash Panda Bijaya Lakshmi Nanda Saswati Satpathy |
| author_facet | Sunanda Dalai Nirupama Devi Jhulana Kumar Jena Jyoti Prakash Panda Bijaya Lakshmi Nanda Saswati Satpathy |
| author_sort | Sunanda Dalai |
| collection | DOAJ |
| description | Introduction: Acute Coronary Syndrome (ACS) is a term that encompasses various clinical presentations such as ST-Segment Elevation Myocardial Infarction (STEMI), Non STEMI (NSTEMI), or unstable angina. Neutrophil Gelatinase-associated Lipocalin (NGAL), also known as lipocalin-2, belongs to the lipocalin category of extracellular proteins. Recent research indicates that NGAL levels are increased in different cardiac situations, regardless of the presence of acute renal injury.
Aim: To compare the levels of serum NGAL and Global Registry of Acute Coronary Events (GRACE) scores between cases with ACS and Angio-negative cases, and to study the correlation of serum NGAL with the GRACE score (clinical severity score) in ACS patients.
Materials and Methods: A cross-sectional study was conducted with 128 patients at the Department of Biochemistry, MKCG Medical College and Hospital, Berhampur, Odisha, India, presenting to the Cardiac Emergency Department from November 2020 to August 2021. Coronary Angiograms (CAG) were done to confirm the presence of Coronary Artery Disease (CAD), and patients were grouped accordingly as Group-1 with ACS patients and Group-2 with angiogram-negative cases. Apart from the routine work-up, including serum urea and creatinine, serum electrolytes, fasting blood sugar, lipid profile, and management, all patients underwent determination of serum NGAL levels and GRACE score at admission. The data were analysis using student’s t-test and Pearson’s correlation test.
Results: Among the 128 participants (64 cases in Group-1 and 64 cases in Group-2), Group-1 comprised 37 cases of STEMI, 26 cases of NSTEMI, and one case of unstable angina. Serum NGAL levels were significantly elevated in patients with CAG-proven ACS (140.89±56.47 ng/mL) without any renal dysfunction, sepsis, or overt infection compared to patients without CAD on CAG (52.01±18.39 ng/mL) (p<0.0001). The serum NGAL level exhibited a positive correlation of 0.359 (p=0.004) with the severity of ACS, as measured by the GRACE score.
Conclusion: The present study suggests that serum NGAL in patients with ACS may serve as a potential novel biomarker for risk stratification and predicting the severity of the disease. |
| first_indexed | 2024-04-24T10:00:04Z |
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| language | English |
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| spelling | doaj.art-ae1779ad13cc41018a7eb160d52b77f52024-04-13T12:19:29ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-04-011804182210.7860/JCDR/2024/66093.19318Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional StudySunanda Dalai0Nirupama Devi1Jhulana Kumar Jena2Jyoti Prakash Panda3Bijaya Lakshmi Nanda4Saswati Satpathy5Assistant Professor, Department of Biochemistry, MKCG Medical College and Hospital, Berhampur, Odisha, India.Professor and Head, Department of Biochemistry, MKCG Medical College and Hospital, Berhampur, Odisha, India.Consultant, Department of Cardiothoracic and Vascular Surgery, Healthworld Hospital, Durgapur, West Bengal, India.Assistant Professor, Department of Biochemistry, SLN Medical College and Hospital, Koraput, Odisha, India.Assistant Professor, Department of Biochemistry, MKCG Medical College and Hospital, Berhampur, Odisha, India.Senior Resident, Department of Biochemistry, SCB Medical College and Hospital, Cuttack, Odisha, India.Introduction: Acute Coronary Syndrome (ACS) is a term that encompasses various clinical presentations such as ST-Segment Elevation Myocardial Infarction (STEMI), Non STEMI (NSTEMI), or unstable angina. Neutrophil Gelatinase-associated Lipocalin (NGAL), also known as lipocalin-2, belongs to the lipocalin category of extracellular proteins. Recent research indicates that NGAL levels are increased in different cardiac situations, regardless of the presence of acute renal injury. Aim: To compare the levels of serum NGAL and Global Registry of Acute Coronary Events (GRACE) scores between cases with ACS and Angio-negative cases, and to study the correlation of serum NGAL with the GRACE score (clinical severity score) in ACS patients. Materials and Methods: A cross-sectional study was conducted with 128 patients at the Department of Biochemistry, MKCG Medical College and Hospital, Berhampur, Odisha, India, presenting to the Cardiac Emergency Department from November 2020 to August 2021. Coronary Angiograms (CAG) were done to confirm the presence of Coronary Artery Disease (CAD), and patients were grouped accordingly as Group-1 with ACS patients and Group-2 with angiogram-negative cases. Apart from the routine work-up, including serum urea and creatinine, serum electrolytes, fasting blood sugar, lipid profile, and management, all patients underwent determination of serum NGAL levels and GRACE score at admission. The data were analysis using student’s t-test and Pearson’s correlation test. Results: Among the 128 participants (64 cases in Group-1 and 64 cases in Group-2), Group-1 comprised 37 cases of STEMI, 26 cases of NSTEMI, and one case of unstable angina. Serum NGAL levels were significantly elevated in patients with CAG-proven ACS (140.89±56.47 ng/mL) without any renal dysfunction, sepsis, or overt infection compared to patients without CAD on CAG (52.01±18.39 ng/mL) (p<0.0001). The serum NGAL level exhibited a positive correlation of 0.359 (p=0.004) with the severity of ACS, as measured by the GRACE score. Conclusion: The present study suggests that serum NGAL in patients with ACS may serve as a potential novel biomarker for risk stratification and predicting the severity of the disease.https://www.jcdr.net/articles/PDF/19318/66093_CE[Ra1]_F(IS)_QC(SD_RDW_IS)_PF1(RI_DK_OM)_PFA(RI_KM)_PN(KM).pdfcoronary angiogramsenzyme-linked immunosorbent assaykidney injuryunstable angina |
| spellingShingle | Sunanda Dalai Nirupama Devi Jhulana Kumar Jena Jyoti Prakash Panda Bijaya Lakshmi Nanda Saswati Satpathy Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study Journal of Clinical and Diagnostic Research coronary angiograms enzyme-linked immunosorbent assay kidney injury unstable angina |
| title | Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study |
| title_full | Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study |
| title_fullStr | Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study |
| title_full_unstemmed | Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study |
| title_short | Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study |
| title_sort | correlation of serum neutrophil gelatinaseassociated lipocalin with clinical severity score in patients with acute coronary syndrome a cross sectional study |
| topic | coronary angiograms enzyme-linked immunosorbent assay kidney injury unstable angina |
| url | https://www.jcdr.net/articles/PDF/19318/66093_CE[Ra1]_F(IS)_QC(SD_RDW_IS)_PF1(RI_DK_OM)_PFA(RI_KM)_PN(KM).pdf |
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