Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice
Aggression is a major hallmark worldwide attributing negative traits in personality. Wide variety of antioxidants is used for the treatment of many ailments. The present study was conducted to evaluate the role of antioxidants such as ascorbic acid (15.42 and 30.84 mg/kg), beta carotene (1.02 and 2....
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00945/full |
| _version_ | 1819072553675653120 |
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| author | Sundas Hira Uzma Saleem Fareeha Anwar Bashir Ahmad |
| author_facet | Sundas Hira Uzma Saleem Fareeha Anwar Bashir Ahmad |
| author_sort | Sundas Hira |
| collection | DOAJ |
| description | Aggression is a major hallmark worldwide attributing negative traits in personality. Wide variety of antioxidants is used for the treatment of many ailments. The present study was conducted to evaluate the role of antioxidants such as ascorbic acid (15.42 and 30.84 mg/kg), beta carotene (1.02 and 2.05 mg/kg), vitamin E (2.5 and 5.0 mg/kg), and N-acetyl cysteine (102.85 and 205.70 mg/kg) in the treatment of aggression. Two aggression models (isolation induced aggression model and L-DOPA induced aggression model) were used in the study. Male albino mice (n = 330) were used in the study which were further subdivided into 11 groups (Group I-control, group II-diseased, group III-standard group, group IV–V treated with ascorbic, group VI–VII treated with beta carotene, group VIII–IX treated with vitamin E, group X–XI treated with N-acetyl cysteine for 14 consecutive days). Different biochemical markers (glutathione, superoxide dismutase, and catalase) were determined to evaluate the antioxidant potential in oxidative stress. High dose of vitamin E (5.0 mg/kg) was more effective to reduce the aggression in isolated animals while all other antioxidants produced dose-dependent anti-aggressive effect except N-acetyl cysteine which had marked anti-aggressive effect at low dose (102.75 mg/kg). Low doses of vitamin E (2.5 mg/kg) and N-acetyl cysteine (102.75 mg/kg) and high dose of beta carotene (2.05 mg/kg) were effective to prevent all aggression parameters in acute anti-aggressive activity against L-DOPA induced aggression. However, all test antioxidants were equally effective in chronic anti-aggressive studies against L-DOPA induced aggression. It may be concluded that selected antioxidants can reverse the aggression which is a key symptom of many neurological disorder. |
| first_indexed | 2024-12-21T17:39:34Z |
| format | Article |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-21T17:39:34Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ae178199779b4a40ae672baf39f059d12022-12-21T18:55:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-01-01810.3389/fphar.2017.00945324661Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in MiceSundas Hira0Uzma Saleem1Fareeha Anwar2Bashir Ahmad3Department of Pharmacy, Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, PakistanFaculty of Pharmaceutical Sciences, Government College University, Faisalabad, PakistanDepartment of Pharmacy, Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, PakistanDepartment of Pharmacy, Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, PakistanAggression is a major hallmark worldwide attributing negative traits in personality. Wide variety of antioxidants is used for the treatment of many ailments. The present study was conducted to evaluate the role of antioxidants such as ascorbic acid (15.42 and 30.84 mg/kg), beta carotene (1.02 and 2.05 mg/kg), vitamin E (2.5 and 5.0 mg/kg), and N-acetyl cysteine (102.85 and 205.70 mg/kg) in the treatment of aggression. Two aggression models (isolation induced aggression model and L-DOPA induced aggression model) were used in the study. Male albino mice (n = 330) were used in the study which were further subdivided into 11 groups (Group I-control, group II-diseased, group III-standard group, group IV–V treated with ascorbic, group VI–VII treated with beta carotene, group VIII–IX treated with vitamin E, group X–XI treated with N-acetyl cysteine for 14 consecutive days). Different biochemical markers (glutathione, superoxide dismutase, and catalase) were determined to evaluate the antioxidant potential in oxidative stress. High dose of vitamin E (5.0 mg/kg) was more effective to reduce the aggression in isolated animals while all other antioxidants produced dose-dependent anti-aggressive effect except N-acetyl cysteine which had marked anti-aggressive effect at low dose (102.75 mg/kg). Low doses of vitamin E (2.5 mg/kg) and N-acetyl cysteine (102.75 mg/kg) and high dose of beta carotene (2.05 mg/kg) were effective to prevent all aggression parameters in acute anti-aggressive activity against L-DOPA induced aggression. However, all test antioxidants were equally effective in chronic anti-aggressive studies against L-DOPA induced aggression. It may be concluded that selected antioxidants can reverse the aggression which is a key symptom of many neurological disorder.http://journal.frontiersin.org/article/10.3389/fphar.2017.00945/fullantioxidantaggressionL-DOPAGSHSODCAT |
| spellingShingle | Sundas Hira Uzma Saleem Fareeha Anwar Bashir Ahmad Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice Frontiers in Pharmacology antioxidant aggression L-DOPA GSH SOD CAT |
| title | Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice |
| title_full | Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice |
| title_fullStr | Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice |
| title_full_unstemmed | Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice |
| title_short | Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice |
| title_sort | antioxidants attenuate isolation and l dopa induced aggression in mice |
| topic | antioxidant aggression L-DOPA GSH SOD CAT |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00945/full |
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