Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation
<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is supposed to have a venous drainage system to a portal vein, which makes intrahepatic metastasis possible. However, the mechanism of extrahepatic recurrence, including the possibility of a direct rout...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/9/1/111 |
| _version_ | 1811257764900503552 |
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| author | Takatsuki Mitsuhisa Yamanouchi Kosho Hamasaki Koji Hidaka Masaaki Soyama Akihiko Miyazaki Kensuke Kanematsu Takashi Eguchi Susumu |
| author_facet | Takatsuki Mitsuhisa Yamanouchi Kosho Hamasaki Koji Hidaka Masaaki Soyama Akihiko Miyazaki Kensuke Kanematsu Takashi Eguchi Susumu |
| author_sort | Takatsuki Mitsuhisa |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is supposed to have a venous drainage system to a portal vein, which makes intrahepatic metastasis possible. However, the mechanism of extrahepatic recurrence, including the possibility of a direct route to the systemic circulation from the HCC nodules, remains unclear. Therefore, we performed retrograde hepatic venography for HCC in livers that had been explanted for liver transplantation in order to explore the possible direct connection between the hepatic vein and HCC nodules.</p> <p>Methods</p> <p>Of 105 living-donor liver transplantations (LDLT) performed up to July, 2009 at the Department of Surgery, Nagasaki University Hospital, dynamic hepatic venography was performed with contrast media under fluoroscopy for the most recent 13 cases with HCC. The presence of a tumor stain for each HCC case was evaluated and compared with the histological findings of HCC.</p> <p>Results</p> <p>Hepatic venography revealed a tumor stain in 2 of 13 cases (15%). Neither showed any microscopic tumor invasion of HCC into the hepatic vein. In the other 11 cases, there were 4 microscopic portal venous invasions and 2 microscopic hepatic venous invasions. No patients have shown HCC recurrence in follow-up (median period, 13 months).</p> <p>Conclusion</p> <p>Using <it>ex vivo </it>hepatic venography, a direct connection to the hepatic vein from HCC in whole liver was revealed in 2 cases without demonstrated histopathological invasion to hepatic vein for the first time in the literature. The finding suggests that there is direct spillage of HCC cells into the systemic circulation via hepatic vein.</p> |
| first_indexed | 2024-04-12T18:02:35Z |
| format | Article |
| id | doaj.art-ae18083d3c49461ab1f1ffd141fb2a6b |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-12T18:02:35Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-ae18083d3c49461ab1f1ffd141fb2a6b2022-12-22T03:22:07ZengBMCWorld Journal of Surgical Oncology1477-78192011-09-019111110.1186/1477-7819-9-111Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantationTakatsuki MitsuhisaYamanouchi KoshoHamasaki KojiHidaka MasaakiSoyama AkihikoMiyazaki KensukeKanematsu TakashiEguchi Susumu<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is supposed to have a venous drainage system to a portal vein, which makes intrahepatic metastasis possible. However, the mechanism of extrahepatic recurrence, including the possibility of a direct route to the systemic circulation from the HCC nodules, remains unclear. Therefore, we performed retrograde hepatic venography for HCC in livers that had been explanted for liver transplantation in order to explore the possible direct connection between the hepatic vein and HCC nodules.</p> <p>Methods</p> <p>Of 105 living-donor liver transplantations (LDLT) performed up to July, 2009 at the Department of Surgery, Nagasaki University Hospital, dynamic hepatic venography was performed with contrast media under fluoroscopy for the most recent 13 cases with HCC. The presence of a tumor stain for each HCC case was evaluated and compared with the histological findings of HCC.</p> <p>Results</p> <p>Hepatic venography revealed a tumor stain in 2 of 13 cases (15%). Neither showed any microscopic tumor invasion of HCC into the hepatic vein. In the other 11 cases, there were 4 microscopic portal venous invasions and 2 microscopic hepatic venous invasions. No patients have shown HCC recurrence in follow-up (median period, 13 months).</p> <p>Conclusion</p> <p>Using <it>ex vivo </it>hepatic venography, a direct connection to the hepatic vein from HCC in whole liver was revealed in 2 cases without demonstrated histopathological invasion to hepatic vein for the first time in the literature. The finding suggests that there is direct spillage of HCC cells into the systemic circulation via hepatic vein.</p>http://www.wjso.com/content/9/1/111 |
| spellingShingle | Takatsuki Mitsuhisa Yamanouchi Kosho Hamasaki Koji Hidaka Masaaki Soyama Akihiko Miyazaki Kensuke Kanematsu Takashi Eguchi Susumu Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation World Journal of Surgical Oncology |
| title | Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation |
| title_full | Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation |
| title_fullStr | Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation |
| title_full_unstemmed | Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation |
| title_short | Ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation |
| title_sort | ex vivo hepatic venography for hepatocellular carcinoma in livers explanted for liver transplantation |
| url | http://www.wjso.com/content/9/1/111 |
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