Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination
BackgroundEfficient early detection methods for lung cancer can significantly decrease patient mortality. One promising approach is the use of tumor-associated autoantibodies (TAABs) as a diagnostic tool. In this study, the researchers aimed to evaluate the potential of seven TAABs in detecting lung...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1166894/full |
| _version_ | 1797852935344881664 |
|---|---|
| author | Zhong Liu Feng Zhang Jianwen Jiang Chenzhao Zhao Lu Zhu Chenbing Liu Nan Li Lihong Qiu Chao Shen Di Sheng Qiang Zeng |
| author_facet | Zhong Liu Feng Zhang Jianwen Jiang Chenzhao Zhao Lu Zhu Chenbing Liu Nan Li Lihong Qiu Chao Shen Di Sheng Qiang Zeng |
| author_sort | Zhong Liu |
| collection | DOAJ |
| description | BackgroundEfficient early detection methods for lung cancer can significantly decrease patient mortality. One promising approach is the use of tumor-associated autoantibodies (TAABs) as a diagnostic tool. In this study, the researchers aimed to evaluate the potential of seven TAABs in detecting lung cancer within a population undergoing routine health examinations. The results of this study could provide valuable insights into the utility of TAABs for lung cancer screening and diagnosis.MethodsIn this study, the serum concentrations of specific antibodies were measured using enzyme-linked immunosorbent assay (ELISA) in a cohort of 15,430 subjects. The efficacy of both a 7-TAAB panel and LDCT for lung cancer detection were evaluated through receiver operating characteristic (ROC) analyses, with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) being assessed and compared. These results could have significant implications for the development of improved screening methods for lung cancer.ResultsOver the 12-month observation period, 26 individuals were diagnosed with lung cancer. The 7-TAAB panel demonstrated promising sensitivity (61.5%) and a high degree of specificity (88.5%). The panel’s area under the receiver operating characteristic (ROC) curve was 0.8062, which was superior to that of any individual TAAB. In stage I patients, the sensitivity of the panel was 50%. In our cohort, there was no gender or age bias observed. This 7-TAAB panel showed a sensitivity of approximately 60% in detecting lung cancer, regardless of histological subtype or lesion size. Notably, ground-glass nodules had a higher diagnostic rate than solid nodules (83.3% vs. 36.4%, P = 0.021). The ROC analyses further revealed that the combination of LDCT with the 7-TAAB assay exhibited a significantly superior diagnostic efficacy than LDCT alone.ConclusionIn the context of the study, it was demonstrated that the 7-TAAB panel showed improved detective efficacy of LDCT, thus serving as an effective aid for the detection of lung cancer in real-world scenarios. |
| first_indexed | 2024-04-09T19:42:22Z |
| format | Article |
| id | doaj.art-ae1a7195625e469eb9a22c17e9dd84c4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T19:42:22Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ae1a7195625e469eb9a22c17e9dd84c42023-04-04T05:16:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11668941166894Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combinationZhong Liu0Feng Zhang1Jianwen Jiang2Chenzhao Zhao3Lu Zhu4Chenbing Liu5Nan Li6Lihong Qiu7Chao Shen8Di Sheng9Qiang Zeng10Health Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHealth Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaBackgroundEfficient early detection methods for lung cancer can significantly decrease patient mortality. One promising approach is the use of tumor-associated autoantibodies (TAABs) as a diagnostic tool. In this study, the researchers aimed to evaluate the potential of seven TAABs in detecting lung cancer within a population undergoing routine health examinations. The results of this study could provide valuable insights into the utility of TAABs for lung cancer screening and diagnosis.MethodsIn this study, the serum concentrations of specific antibodies were measured using enzyme-linked immunosorbent assay (ELISA) in a cohort of 15,430 subjects. The efficacy of both a 7-TAAB panel and LDCT for lung cancer detection were evaluated through receiver operating characteristic (ROC) analyses, with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) being assessed and compared. These results could have significant implications for the development of improved screening methods for lung cancer.ResultsOver the 12-month observation period, 26 individuals were diagnosed with lung cancer. The 7-TAAB panel demonstrated promising sensitivity (61.5%) and a high degree of specificity (88.5%). The panel’s area under the receiver operating characteristic (ROC) curve was 0.8062, which was superior to that of any individual TAAB. In stage I patients, the sensitivity of the panel was 50%. In our cohort, there was no gender or age bias observed. This 7-TAAB panel showed a sensitivity of approximately 60% in detecting lung cancer, regardless of histological subtype or lesion size. Notably, ground-glass nodules had a higher diagnostic rate than solid nodules (83.3% vs. 36.4%, P = 0.021). The ROC analyses further revealed that the combination of LDCT with the 7-TAAB assay exhibited a significantly superior diagnostic efficacy than LDCT alone.ConclusionIn the context of the study, it was demonstrated that the 7-TAAB panel showed improved detective efficacy of LDCT, thus serving as an effective aid for the detection of lung cancer in real-world scenarios.https://www.frontiersin.org/articles/10.3389/fonc.2023.1166894/fulllung cancerautoantibodyLDCTimmuneearly detection |
| spellingShingle | Zhong Liu Feng Zhang Jianwen Jiang Chenzhao Zhao Lu Zhu Chenbing Liu Nan Li Lihong Qiu Chao Shen Di Sheng Qiang Zeng Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination Frontiers in Oncology lung cancer autoantibody LDCT immune early detection |
| title | Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination |
| title_full | Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination |
| title_fullStr | Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination |
| title_full_unstemmed | Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination |
| title_short | Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination |
| title_sort | early detection of lung cancer in a real world cohort via tumor associated immune autoantibody and imaging combination |
| topic | lung cancer autoantibody LDCT immune early detection |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1166894/full |
| work_keys_str_mv | AT zhongliu earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT fengzhang earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT jianwenjiang earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT chenzhaozhao earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT luzhu earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT chenbingliu earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT nanli earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT lihongqiu earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT chaoshen earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT disheng earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination AT qiangzeng earlydetectionoflungcancerinarealworldcohortviatumorassociatedimmuneautoantibodyandimagingcombination |