Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue
<b>Purpose:</b> In this study we aimed to estimate the effectiveness of pharmacological, nutraceutical, and phytopharmaceutical treatments on CRF. <b>Methods:</b> Ovid MEDLINE, Ovid Embase, Ovid Psych info, CINHAHL and Cochrane Library databases were searched up to 30 Septemb...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/1/91 |
| _version_ | 1797626202135986176 |
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| author | Sriram Yennurajalingam Zhanni Lu Aline Rozman De Moraes Nhu Nhu Tull Michal J. Kubiak Yimin Geng Clark R. Andersen Eduardo Bruera |
| author_facet | Sriram Yennurajalingam Zhanni Lu Aline Rozman De Moraes Nhu Nhu Tull Michal J. Kubiak Yimin Geng Clark R. Andersen Eduardo Bruera |
| author_sort | Sriram Yennurajalingam |
| collection | DOAJ |
| description | <b>Purpose:</b> In this study we aimed to estimate the effectiveness of pharmacological, nutraceutical, and phytopharmaceutical treatments on CRF. <b>Methods:</b> Ovid MEDLINE, Ovid Embase, Ovid Psych info, CINHAHL and Cochrane Library databases were searched up to 30 September 2021. Randomized controlled trials of pharmacological, nutraceutical and phytopharmaceutical interventions for treatment of CRF for at least one week duration and have used valid tool to assess severity of CRF as a primary or secondary outcome were considered. <b>Results</b>: 32 eligible studies (4896 patients) were reviewed. For the overall meta-analysis, the random effect models yielded the treatment effect (95% CI) of −0.29 (−0.48,−0.09), <i>p</i> < 0.001. The meta-analysis did not show significant reduction of CRF with treatment with ginseng (n = 6), guarana (n = 3), megestrol (n = 2), mistletoe (n = 3), psychostimulants (n = 14), SSRI/antidepressants (n = 2). Corticosteroids (n = 2) showed significant reduction in CRF with treatment effects of 0.94 (−1.21, −0.67), <i>p</i> <0.0001, respectively. <b>Conclusions</b>: In this study, overall meta-analysis of all studies demonstrates significant reduction of CRF using Pharmacological, Nutraceutical and Phytopharmaceutical interventions with a pooled standardized treatment effect of −0.29. Metanalysis of Corticosteroids studies showed significant reduction in CRF. Further studies are needed. |
| first_indexed | 2024-03-11T10:07:06Z |
| format | Article |
| id | doaj.art-ae1a7ca02da743d2878e7830f2a8201b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:07:06Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ae1a7ca02da743d2878e7830f2a8201b2023-11-16T15:01:30ZengMDPI AGCancers2072-66942022-12-011519110.3390/cancers15010091Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related FatigueSriram Yennurajalingam0Zhanni Lu1Aline Rozman De Moraes2Nhu Nhu Tull3Michal J. Kubiak4Yimin Geng5Clark R. Andersen6Eduardo Bruera7Department of Palliative Care Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Palliative Care Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Palliative Care Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Palliative Care Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Palliative Care Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAResearch Medical Library, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Palliative Care Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA<b>Purpose:</b> In this study we aimed to estimate the effectiveness of pharmacological, nutraceutical, and phytopharmaceutical treatments on CRF. <b>Methods:</b> Ovid MEDLINE, Ovid Embase, Ovid Psych info, CINHAHL and Cochrane Library databases were searched up to 30 September 2021. Randomized controlled trials of pharmacological, nutraceutical and phytopharmaceutical interventions for treatment of CRF for at least one week duration and have used valid tool to assess severity of CRF as a primary or secondary outcome were considered. <b>Results</b>: 32 eligible studies (4896 patients) were reviewed. For the overall meta-analysis, the random effect models yielded the treatment effect (95% CI) of −0.29 (−0.48,−0.09), <i>p</i> < 0.001. The meta-analysis did not show significant reduction of CRF with treatment with ginseng (n = 6), guarana (n = 3), megestrol (n = 2), mistletoe (n = 3), psychostimulants (n = 14), SSRI/antidepressants (n = 2). Corticosteroids (n = 2) showed significant reduction in CRF with treatment effects of 0.94 (−1.21, −0.67), <i>p</i> <0.0001, respectively. <b>Conclusions</b>: In this study, overall meta-analysis of all studies demonstrates significant reduction of CRF using Pharmacological, Nutraceutical and Phytopharmaceutical interventions with a pooled standardized treatment effect of −0.29. Metanalysis of Corticosteroids studies showed significant reduction in CRF. Further studies are needed.https://www.mdpi.com/2072-6694/15/1/91cancerfatiguemetanalysispharmacologicalnutraceuticalsphytopharmaceuticals |
| spellingShingle | Sriram Yennurajalingam Zhanni Lu Aline Rozman De Moraes Nhu Nhu Tull Michal J. Kubiak Yimin Geng Clark R. Andersen Eduardo Bruera Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue Cancers cancer fatigue metanalysis pharmacological nutraceuticals phytopharmaceuticals |
| title | Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue |
| title_full | Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue |
| title_fullStr | Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue |
| title_full_unstemmed | Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue |
| title_short | Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue |
| title_sort | meta analysis of pharmacological nutraceutical and phytopharmaceutical interventions for the treatment of cancer related fatigue |
| topic | cancer fatigue metanalysis pharmacological nutraceuticals phytopharmaceuticals |
| url | https://www.mdpi.com/2072-6694/15/1/91 |
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