Organoids: A New Chapter in Sarcoma Diagnosis and Treatment
Sarcomas are malignant tumors of mesenchymal origin that can occur at any age. The rarity of these tumors in combination with the vast number of histological subtypes render the study of sarcomas challenging. Organoids represent complex three-dimensional cell culture systems, deriving from stem cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11271 |
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| author | Iason Psilopatis Stefania Kokkali Kostas Palamaris Antonia Digklia Kleio Vrettou Stamatios Theocharis |
| author_facet | Iason Psilopatis Stefania Kokkali Kostas Palamaris Antonia Digklia Kleio Vrettou Stamatios Theocharis |
| author_sort | Iason Psilopatis |
| collection | DOAJ |
| description | Sarcomas are malignant tumors of mesenchymal origin that can occur at any age. The rarity of these tumors in combination with the vast number of histological subtypes render the study of sarcomas challenging. Organoids represent complex three-dimensional cell culture systems, deriving from stem cells and preserving the capacity to differentiate into the cell types of their tissue of origin. The aim of the present review is to study the current status of patient-derived organoids, as well as their potential to model tumorigenesis and perform drug screenings for sarcomas. In order to identify relevant studies, a literature review was conducted and we were able to identify 16 studies published between 2019 and 2022. The current manuscript represents the first comprehensive review of the literature focusing on the use of organoids for disease modelling and drug sensitivity testing in diverse sarcoma subtypes. |
| first_indexed | 2024-03-09T21:41:15Z |
| format | Article |
| id | doaj.art-ae1c5a3e3a1940d7ba510626e86ff17a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:41:15Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ae1c5a3e3a1940d7ba510626e86ff17a2023-11-23T20:30:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123191127110.3390/ijms231911271Organoids: A New Chapter in Sarcoma Diagnosis and TreatmentIason Psilopatis0Stefania Kokkali1Kostas Palamaris2Antonia Digklia3Kleio Vrettou4Stamatios Theocharis5Department of Gynecology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt–Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceDepartment of Oncology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, SwitzerlandFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceSarcomas are malignant tumors of mesenchymal origin that can occur at any age. The rarity of these tumors in combination with the vast number of histological subtypes render the study of sarcomas challenging. Organoids represent complex three-dimensional cell culture systems, deriving from stem cells and preserving the capacity to differentiate into the cell types of their tissue of origin. The aim of the present review is to study the current status of patient-derived organoids, as well as their potential to model tumorigenesis and perform drug screenings for sarcomas. In order to identify relevant studies, a literature review was conducted and we were able to identify 16 studies published between 2019 and 2022. The current manuscript represents the first comprehensive review of the literature focusing on the use of organoids for disease modelling and drug sensitivity testing in diverse sarcoma subtypes.https://www.mdpi.com/1422-0067/23/19/11271organoidssarcomathree-dimensional cell culture |
| spellingShingle | Iason Psilopatis Stefania Kokkali Kostas Palamaris Antonia Digklia Kleio Vrettou Stamatios Theocharis Organoids: A New Chapter in Sarcoma Diagnosis and Treatment International Journal of Molecular Sciences organoids sarcoma three-dimensional cell culture |
| title | Organoids: A New Chapter in Sarcoma Diagnosis and Treatment |
| title_full | Organoids: A New Chapter in Sarcoma Diagnosis and Treatment |
| title_fullStr | Organoids: A New Chapter in Sarcoma Diagnosis and Treatment |
| title_full_unstemmed | Organoids: A New Chapter in Sarcoma Diagnosis and Treatment |
| title_short | Organoids: A New Chapter in Sarcoma Diagnosis and Treatment |
| title_sort | organoids a new chapter in sarcoma diagnosis and treatment |
| topic | organoids sarcoma three-dimensional cell culture |
| url | https://www.mdpi.com/1422-0067/23/19/11271 |
| work_keys_str_mv | AT iasonpsilopatis organoidsanewchapterinsarcomadiagnosisandtreatment AT stefaniakokkali organoidsanewchapterinsarcomadiagnosisandtreatment AT kostaspalamaris organoidsanewchapterinsarcomadiagnosisandtreatment AT antoniadigklia organoidsanewchapterinsarcomadiagnosisandtreatment AT kleiovrettou organoidsanewchapterinsarcomadiagnosisandtreatment AT stamatiostheocharis organoidsanewchapterinsarcomadiagnosisandtreatment |