Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems
Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility, which may jeopardize optimal treatment. Therefor...
Main Authors: | Annemarie Broesder, Julia M. E. Berends, Sophie M. Scheepers, Duong N. Nguyen, Henderik W. Frijlink, Wouter L. J. Hinrichs |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/13/5/731 |
Similar Items
-
Formulation and In Vitro Evaluation of Pellets Containing Sulfasalazine and Caffeine to Verify Ileo-Colonic Drug Delivery
by: Annemarie Broesder, et al.
Published: (2021-11-01) -
Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process
by: Bahez Gareb, et al.
Published: (2019-08-01) -
İleoçekal valvüle çok yakın yapılan ileo-ileal anastomoz
by: Emin Köse
Published: (2016-12-01) -
Íleo Biliar como causa de obstrucción intestinal.
by: Luis Alberto Martínez Cruz, et al.
Published: (2023-02-01) -
Tuberculous ileo-vesical fistula with ileal obstruction
by: Ajay Kanbur, et al.
Published: (2000-01-01)