The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury
Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce liver injury. Moreover, DILI is the main cause o...
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| Format: | Article |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.723940/full |
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| author | Wenhui Liu Wenhui Liu Wenhui Liu Wenhui Liu Xiangchang Zeng Xiangchang Zeng Xiangchang Zeng Xiangchang Zeng Yating Liu Yating Liu Yating Liu Yating Liu Jinfeng Liu Jinfeng Liu Jinfeng Liu Jinfeng Liu Chaopeng Li Lulu Chen Hongying Chen Hongying Chen Hongying Chen Hongying Chen Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang |
| author_facet | Wenhui Liu Wenhui Liu Wenhui Liu Wenhui Liu Xiangchang Zeng Xiangchang Zeng Xiangchang Zeng Xiangchang Zeng Yating Liu Yating Liu Yating Liu Yating Liu Jinfeng Liu Jinfeng Liu Jinfeng Liu Jinfeng Liu Chaopeng Li Lulu Chen Hongying Chen Hongying Chen Hongying Chen Hongying Chen Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang |
| author_sort | Wenhui Liu |
| collection | DOAJ |
| description | Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce liver injury. Moreover, DILI is the main cause of the interruption of new drugs development and drugs withdrawn from the pharmaceutical market. Acute DILI may evolve into chronic DILI or even worse, commonly lead to life-threatening acute liver failure in Western countries. It is generally considered to have a close relationship to genetic factors, environmental risk factors, and host immunity, through the drug itself or its metabolites, leading to a series of cellular events, such as haptenization and immune response activation. Despite many researches on DILI, the specific biomarkers about it are not applicable to clinical diagnosis, which still relies on the exclusion of other causes of liver disease in clinical practice as before. Additionally, circumstantial evidence has suggested that DILI is mediated by the immune system. Here, we review the underlying mechanisms of the immune response to DILI and provide guidance for the future development of biomarkers for the early detection, prediction, and diagnosis of DILI. |
| first_indexed | 2024-12-21T04:22:23Z |
| format | Article |
| id | doaj.art-ae214a4b7a3b4f6789efb9e9726a956c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T04:22:23Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ae214a4b7a3b4f6789efb9e9726a956c2022-12-21T19:16:09ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.723940723940The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver InjuryWenhui Liu0Wenhui Liu1Wenhui Liu2Wenhui Liu3Xiangchang Zeng4Xiangchang Zeng5Xiangchang Zeng6Xiangchang Zeng7Yating Liu8Yating Liu9Yating Liu10Yating Liu11Jinfeng Liu12Jinfeng Liu13Jinfeng Liu14Jinfeng Liu15Chaopeng Li16Lulu Chen17Hongying Chen18Hongying Chen19Hongying Chen20Hongying Chen21Dongsheng Ouyang22Dongsheng Ouyang23Dongsheng Ouyang24Dongsheng Ouyang25Dongsheng Ouyang26Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, ChinaEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, ChinaEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, ChinaEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, ChinaEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaHunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha Duxact Biotech Co., Ltd., Changsha, ChinaHunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha Duxact Biotech Co., Ltd., Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, ChinaEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, ChinaEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaHunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha Duxact Biotech Co., Ltd., Changsha, ChinaDrug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce liver injury. Moreover, DILI is the main cause of the interruption of new drugs development and drugs withdrawn from the pharmaceutical market. Acute DILI may evolve into chronic DILI or even worse, commonly lead to life-threatening acute liver failure in Western countries. It is generally considered to have a close relationship to genetic factors, environmental risk factors, and host immunity, through the drug itself or its metabolites, leading to a series of cellular events, such as haptenization and immune response activation. Despite many researches on DILI, the specific biomarkers about it are not applicable to clinical diagnosis, which still relies on the exclusion of other causes of liver disease in clinical practice as before. Additionally, circumstantial evidence has suggested that DILI is mediated by the immune system. Here, we review the underlying mechanisms of the immune response to DILI and provide guidance for the future development of biomarkers for the early detection, prediction, and diagnosis of DILI.https://www.frontiersin.org/articles/10.3389/fphar.2021.723940/fulldrug-induced liver injurymechanismimmune responseimmunebiomarker |
| spellingShingle | Wenhui Liu Wenhui Liu Wenhui Liu Wenhui Liu Xiangchang Zeng Xiangchang Zeng Xiangchang Zeng Xiangchang Zeng Yating Liu Yating Liu Yating Liu Yating Liu Jinfeng Liu Jinfeng Liu Jinfeng Liu Jinfeng Liu Chaopeng Li Lulu Chen Hongying Chen Hongying Chen Hongying Chen Hongying Chen Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang Dongsheng Ouyang The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury Frontiers in Pharmacology drug-induced liver injury mechanism immune response immune biomarker |
| title | The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury |
| title_full | The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury |
| title_fullStr | The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury |
| title_full_unstemmed | The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury |
| title_short | The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury |
| title_sort | immunological mechanisms and immune based biomarkers of drug induced liver injury |
| topic | drug-induced liver injury mechanism immune response immune biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.723940/full |
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