The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice
Background & aim: Treatment of cutaneous leishmaniasis (CL) is based on the use of pentavalent antimony compounds as injection drug with highly side effects. The purpose of this study was to evaluate the effect(s) of chamomile tea on cutaneous leishmaniasis caused by Leishmania major in Balb/C m...
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| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2015-05-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-297&slc_lang=en&sid=1 |
| _version_ | 1811236709762859008 |
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| author | AR Dashtpeima AA Moshfe L Manzoori N Arefkhah S Shahryari M Mohseni M Abbasi J Noushadian |
| author_facet | AR Dashtpeima AA Moshfe L Manzoori N Arefkhah S Shahryari M Mohseni M Abbasi J Noushadian |
| author_sort | AR Dashtpeima |
| collection | DOAJ |
| description | Background & aim: Treatment of cutaneous leishmaniasis (CL) is based on the use of pentavalent antimony compounds as injection drug with highly side effects. The purpose of this study was to evaluate the effect(s) of chamomile tea on cutaneous leishmaniasis caused by Leishmania major in Balb/C mice.
Methods: In the present experimental study, 22 male Balb C mice were inoculated with L. major promastigotes at the base of their tail to cause leishmaniasis ulcers. Then, the mice were divided into three groups of treated with chamomile tea, group treated with Glucantime, and an untreated group. In a period of two weeks, the first group was exposed to chamomile tea for 5 minutes every day, and the second group received glucantime intra-peritoneally. Finally, the size and the situation of wound healing at the beginning and at end of the study were evaluated. The collected data were analyzed using paired t-tests, ANOVA and Tukey tests.
Results: The comparison of these three groups revealed that wound healing in group one and group two were 58.3% and 80% respectively, which was significant whereas no healing was seen in the control group (p=0.028). The average area of lesions in the three groups after treatment showed statistically significant difference (p=0.0001), but no significant diffrence was observed in the average area of lesions in the two groups of Glucantime and chamomile tea.
Conclusion: According to the results, the effect of chamomile tea on cutaneous wound healing was similar to tomeglumine antimoniate (Glunantime). With regard to the side effects of pentavalent antimony compounds, the chamomile tea can be recommended as an alternative drug for treatment of leishmaniasis ulcer. |
| first_indexed | 2024-04-12T12:12:41Z |
| format | Article |
| id | doaj.art-ae21f4fa053a429385e92d2f67814842 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-12T12:12:41Z |
| publishDate | 2015-05-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-ae21f4fa053a429385e92d2f678148422022-12-22T03:33:31ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142015-05-01202127137The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c MiceAR Dashtpeima0AA Moshfe1L Manzoori2N Arefkhah3S Shahryari4M Mohseni5M Abbasi6J Noushadian7 Student Research Committee, Yasuj of University of Medical Sciences, Yasuj, Iran Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran 4Department of Parasitology, Yasuj University of Medical Sciences, Yasuj, Iran, 5Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran 6Faculty of Veterinary Medicine, Shahrekord Branch, Islamic azad University, Shahrekord, Iran Yasuj University of Medical Sciences, Yasuj, Iran Yasuj University of Medical Sciences, Yasuj, Iran Background & aim: Treatment of cutaneous leishmaniasis (CL) is based on the use of pentavalent antimony compounds as injection drug with highly side effects. The purpose of this study was to evaluate the effect(s) of chamomile tea on cutaneous leishmaniasis caused by Leishmania major in Balb/C mice. Methods: In the present experimental study, 22 male Balb C mice were inoculated with L. major promastigotes at the base of their tail to cause leishmaniasis ulcers. Then, the mice were divided into three groups of treated with chamomile tea, group treated with Glucantime, and an untreated group. In a period of two weeks, the first group was exposed to chamomile tea for 5 minutes every day, and the second group received glucantime intra-peritoneally. Finally, the size and the situation of wound healing at the beginning and at end of the study were evaluated. The collected data were analyzed using paired t-tests, ANOVA and Tukey tests. Results: The comparison of these three groups revealed that wound healing in group one and group two were 58.3% and 80% respectively, which was significant whereas no healing was seen in the control group (p=0.028). The average area of lesions in the three groups after treatment showed statistically significant difference (p=0.0001), but no significant diffrence was observed in the average area of lesions in the two groups of Glucantime and chamomile tea. Conclusion: According to the results, the effect of chamomile tea on cutaneous wound healing was similar to tomeglumine antimoniate (Glunantime). With regard to the side effects of pentavalent antimony compounds, the chamomile tea can be recommended as an alternative drug for treatment of leishmaniasis ulcer.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-297&slc_lang=en&sid=1Leishmania major Matricaria chamomilla Treatment Balb/c mice |
| spellingShingle | AR Dashtpeima AA Moshfe L Manzoori N Arefkhah S Shahryari M Mohseni M Abbasi J Noushadian The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice Armaghane Danesh Bimonthly Journal Leishmania major Matricaria chamomilla Treatment Balb/c mice |
| title | The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice |
| title_full | The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice |
| title_fullStr | The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice |
| title_full_unstemmed | The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice |
| title_short | The Effect(s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice |
| title_sort | effect s of matricaria chamomilla on leishmania major ulcers in balb c mice |
| topic | Leishmania major Matricaria chamomilla Treatment Balb/c mice |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-297&slc_lang=en&sid=1 |
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