HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases
Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and inflammation contributes substantially to its occurrence and progression. The prevalence of CVD increases as the population ages, and the pathophysiology is complex. Anti-inflammatory and immunological modulation ar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223009095 |
| _version_ | 1797744082260328448 |
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| author | Xialei Zheng Junmi Lu Jing Liu Liufang Zhou Yuhu He |
| author_facet | Xialei Zheng Junmi Lu Jing Liu Liufang Zhou Yuhu He |
| author_sort | Xialei Zheng |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and inflammation contributes substantially to its occurrence and progression. The prevalence of CVD increases as the population ages, and the pathophysiology is complex. Anti-inflammatory and immunological modulation are the potential methods for CVD prevention and treatment. High-Mobility Group (HMG) chromosomal proteins are one of the most abundant nuclear nonhistone proteins which act as inflammatory mediators in DNA replication, transcription, and repair by producing cytokines and serving as damage-associated molecular patterns in inflammatory responses. The most common and well-studied HMG proteins are those with an HMGB domain, which participate in a variety of biological processes. HMGB1 and HMGB2 were the first members of the HMGB family to be identified and are present in all investigated eukaryotes. Our review is primarily concerned with the involvement of HMGB1 and HMGB2 in CVD. The purpose of this review is to provide a theoretical framework for diagnosing and treating CVD by discussing the structure and function of HMGB1 and HMGB2. |
| first_indexed | 2024-03-12T15:05:36Z |
| format | Article |
| id | doaj.art-ae256cf7d2684ceeaf15503d070a7912 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:05:36Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-ae256cf7d2684ceeaf15503d070a79122023-08-13T04:52:39ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115118HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseasesXialei Zheng0Junmi Lu1Jing Liu2Liufang Zhou3Yuhu He4Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Department of Cardiovascular Medicine, the Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi 533000, ChinaDepartment of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Corresponding author.Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and inflammation contributes substantially to its occurrence and progression. The prevalence of CVD increases as the population ages, and the pathophysiology is complex. Anti-inflammatory and immunological modulation are the potential methods for CVD prevention and treatment. High-Mobility Group (HMG) chromosomal proteins are one of the most abundant nuclear nonhistone proteins which act as inflammatory mediators in DNA replication, transcription, and repair by producing cytokines and serving as damage-associated molecular patterns in inflammatory responses. The most common and well-studied HMG proteins are those with an HMGB domain, which participate in a variety of biological processes. HMGB1 and HMGB2 were the first members of the HMGB family to be identified and are present in all investigated eukaryotes. Our review is primarily concerned with the involvement of HMGB1 and HMGB2 in CVD. The purpose of this review is to provide a theoretical framework for diagnosing and treating CVD by discussing the structure and function of HMGB1 and HMGB2.http://www.sciencedirect.com/science/article/pii/S0753332223009095HMGB1HMGB2Cardiovascular diseaseInflammationHigh-mobility group |
| spellingShingle | Xialei Zheng Junmi Lu Jing Liu Liufang Zhou Yuhu He HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases Biomedicine & Pharmacotherapy HMGB1 HMGB2 Cardiovascular disease Inflammation High-mobility group |
| title | HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases |
| title_full | HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases |
| title_fullStr | HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases |
| title_full_unstemmed | HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases |
| title_short | HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases |
| title_sort | hmgb family proteins potential biomarkers and mechanistic factors in cardiovascular diseases |
| topic | HMGB1 HMGB2 Cardiovascular disease Inflammation High-mobility group |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223009095 |
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