Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics
Rapid detection of harmful estrogens in cosmetics is essential in protecting public health. To reduce time-consuming pretreatment and analytical procedures, a novel reactive paper spray ionization mass spectrometry (RPSI-MS) methodology was developed. RPSI-MS is suitable for quantitatively analyzing...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5675 |
| _version_ | 1797586404071440384 |
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| author | Dongning Song Jing Liu Yang Liu |
| author_facet | Dongning Song Jing Liu Yang Liu |
| author_sort | Dongning Song |
| collection | DOAJ |
| description | Rapid detection of harmful estrogens in cosmetics is essential in protecting public health. To reduce time-consuming pretreatment and analytical procedures, a novel reactive paper spray ionization mass spectrometry (RPSI-MS) methodology was developed. RPSI-MS is suitable for quantitatively analyzing estrogens in cosmetics by utilizing an online derivatization reaction between estrogens and 2-fluoro-1-methyl-pyridinium-p-toluene-sulfonate (FluMP). Using estradiol valerate as the internal standard (I.S.), three estrogens, estradiol, estriol, and ethinyloestradiol, in cosmetics were quantitatively characterized within minutes. Multiple parameters were optimized including FluMP concentration and volume, triethylamine amount as well as the drying time. The three estrogens displayed good linearity ranging from 0.002 to 1 μg/mL, with R<sup>2</sup> above 0.99. The recovery results of all the estrogens were within 80~111%. The limit of detection (LOD) was 0.001 μg/mL for the three estrogens. Compared to conventional paper spray ionization mass spectrometry (PSI-MS), extraction is not required and the detection sensitivity of RPSI-MS was improved by 34,000, 80,000, and 1400 times for estradiol, estriol, and ethinyloestradiol, respectively. The protocol established in this paper is sensitive, eco-friendly, and suitable for rapid testing of estrogens in cosmetics. |
| first_indexed | 2024-03-11T00:21:47Z |
| format | Article |
| id | doaj.art-ae267585d3cf4f1ab5ee15b74e47e330 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:21:47Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ae267585d3cf4f1ab5ee15b74e47e3302023-11-18T23:17:27ZengMDPI AGMolecules1420-30492023-07-012815567510.3390/molecules28155675Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in CosmeticsDongning Song0Jing Liu1Yang Liu2National Institutes for Food and Drug Control, Beijing 102629, ChinaNational Institutes for Food and Drug Control, Beijing 102629, ChinaNational Institutes for Food and Drug Control, Beijing 102629, ChinaRapid detection of harmful estrogens in cosmetics is essential in protecting public health. To reduce time-consuming pretreatment and analytical procedures, a novel reactive paper spray ionization mass spectrometry (RPSI-MS) methodology was developed. RPSI-MS is suitable for quantitatively analyzing estrogens in cosmetics by utilizing an online derivatization reaction between estrogens and 2-fluoro-1-methyl-pyridinium-p-toluene-sulfonate (FluMP). Using estradiol valerate as the internal standard (I.S.), three estrogens, estradiol, estriol, and ethinyloestradiol, in cosmetics were quantitatively characterized within minutes. Multiple parameters were optimized including FluMP concentration and volume, triethylamine amount as well as the drying time. The three estrogens displayed good linearity ranging from 0.002 to 1 μg/mL, with R<sup>2</sup> above 0.99. The recovery results of all the estrogens were within 80~111%. The limit of detection (LOD) was 0.001 μg/mL for the three estrogens. Compared to conventional paper spray ionization mass spectrometry (PSI-MS), extraction is not required and the detection sensitivity of RPSI-MS was improved by 34,000, 80,000, and 1400 times for estradiol, estriol, and ethinyloestradiol, respectively. The protocol established in this paper is sensitive, eco-friendly, and suitable for rapid testing of estrogens in cosmetics.https://www.mdpi.com/1420-3049/28/15/5675RPSIestrogenscosmeticsonline derivatization |
| spellingShingle | Dongning Song Jing Liu Yang Liu Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics Molecules RPSI estrogens cosmetics online derivatization |
| title | Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics |
| title_full | Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics |
| title_fullStr | Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics |
| title_full_unstemmed | Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics |
| title_short | Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics |
| title_sort | reactive paper spray ionization mass spectrometry for rapid detection of estrogens in cosmetics |
| topic | RPSI estrogens cosmetics online derivatization |
| url | https://www.mdpi.com/1420-3049/28/15/5675 |
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