Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients
Epstein-Barr virus (EBV) is asymptomatic in most cases, however, the virus can be linked to pre-malignant lymphoproliferative diseases and to distinct human tumors. They can be classified as leiomyomas or leiomyosarcomas. Diagnosis depends on histopathology and EBV detection. Symptoms are associated...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Pediatric Surgery Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213576622002731 |
| _version_ | 1811202105667485696 |
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| author | Juliana Antinarelli Norberto da Silva Patricio Cieri Alexandre Alberto Barros Duarte Fernanda Kelly Marques de Souza Eliana Maria Monteiro Caran Maria Teresa Alves de Seixas Paola de La Iglesia Niveyro Paula A. Coccia Pablo Lobos Simone de Campos Vieira Abib |
| author_facet | Juliana Antinarelli Norberto da Silva Patricio Cieri Alexandre Alberto Barros Duarte Fernanda Kelly Marques de Souza Eliana Maria Monteiro Caran Maria Teresa Alves de Seixas Paola de La Iglesia Niveyro Paula A. Coccia Pablo Lobos Simone de Campos Vieira Abib |
| author_sort | Juliana Antinarelli Norberto da Silva |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) is asymptomatic in most cases, however, the virus can be linked to pre-malignant lymphoproliferative diseases and to distinct human tumors. They can be classified as leiomyomas or leiomyosarcomas. Diagnosis depends on histopathology and EBV detection. Symptoms are associated with the lesion site. Various treatment modalities are described. It is mainly based on surgical resection, when possible, associated with reduced immunosuppression. It is also associated with targeted therapy and antiviral drugs. The role of surgery and chemotherapy are not well defined yet.A retrospective analysis of patients treated with this diagnosis was carried out at the Pediatric Oncology Institute - GRAACC/UNIFESP - Brazil and Hospital Italiano de Buenos Aires - Argentina, in the period from 2000 to 2020. Three medical records were found and the cases are described. All patients were immunocompromised. Two underwent resection of the tumoral lesion and one only clinical treatment and follow-up because tumors were considered unresectable. Long-term follow-up shows the importance of surgical resection. Surgery has a role in diagnosis too.This tumor is rare, especially in pediatric patients. Although surgical resection has impact in the long-term follow up, surgical treatment should be tailored depending on tumor resectability for each patient. |
| first_indexed | 2024-04-12T02:33:23Z |
| format | Article |
| id | doaj.art-ae26cfea05274d8784c75ac1a8783f50 |
| institution | Directory Open Access Journal |
| issn | 2213-5766 |
| language | English |
| last_indexed | 2024-04-12T02:33:23Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pediatric Surgery Case Reports |
| spelling | doaj.art-ae26cfea05274d8784c75ac1a8783f502022-12-22T03:51:39ZengElsevierJournal of Pediatric Surgery Case Reports2213-57662023-01-0188102446Smooth muscle tumor associated with Epstein Barr-virus in pediatric patientsJuliana Antinarelli Norberto da Silva0Patricio Cieri1Alexandre Alberto Barros Duarte2Fernanda Kelly Marques de Souza3Eliana Maria Monteiro Caran4Maria Teresa Alves de Seixas5Paola de La Iglesia Niveyro6Paula A. Coccia7Pablo Lobos8Simone de Campos Vieira Abib9Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil; Department of Pediatric Surgery - Pediatric Oncology Institute - GRAACC – Federal University of São Paulo, BrazilTte. Gral. Juan Domingo Péron 4190, CABA, CP C1199ABB, Buenos Aires, Argentina; Department of Pediatric Surgery, Hospital Italiano de Buenos Aires, ArgentinaRua Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil; Department of Pediatric Surgery - Pediatric Oncology Institute - GRAACC – Federal University of São Paulo, BrazilRua Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil; Department of Pediatric Surgery - Pediatric Oncology Institute - GRAACC – Federal University of São Paulo, BrazilRua Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil; Department of Pediatric Surgery - Pediatric Oncology Institute - GRAACC – Federal University of São Paulo, BrazilRua Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil; Department of Pediatric Surgery - Pediatric Oncology Institute - GRAACC – Federal University of São Paulo, BrazilTte. Gral. Juan Domingo Péron 4190, CABA, CP C1199ABB, Buenos Aires, Argentina; Department of Anatomic Pathology, Hospital Italiano de Buenos Aires, ArgentinaTte. Gral. Juan Domingo Péron 4190, CABA, CP C1199ABB, Buenos Aires, Argentina; Department of Pediatric Nephrology, Hospital Italiano de Buenos Aires, ArgentinaTte. Gral. Juan Domingo Péron 4190, CABA, CP C1199ABB, Buenos Aires, Argentina; Department of Pediatric Surgery, Hospital Italiano de Buenos Aires, ArgentinaRua Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil; Department of Pediatric Surgery - Pediatric Oncology Institute - GRAACC – Federal University of São Paulo, Brazil; Corresponding author. Rua Pedro de Toledo, 572 - Vila Clementino, São Paulo, 04039-001, Brazil.Epstein-Barr virus (EBV) is asymptomatic in most cases, however, the virus can be linked to pre-malignant lymphoproliferative diseases and to distinct human tumors. They can be classified as leiomyomas or leiomyosarcomas. Diagnosis depends on histopathology and EBV detection. Symptoms are associated with the lesion site. Various treatment modalities are described. It is mainly based on surgical resection, when possible, associated with reduced immunosuppression. It is also associated with targeted therapy and antiviral drugs. The role of surgery and chemotherapy are not well defined yet.A retrospective analysis of patients treated with this diagnosis was carried out at the Pediatric Oncology Institute - GRAACC/UNIFESP - Brazil and Hospital Italiano de Buenos Aires - Argentina, in the period from 2000 to 2020. Three medical records were found and the cases are described. All patients were immunocompromised. Two underwent resection of the tumoral lesion and one only clinical treatment and follow-up because tumors were considered unresectable. Long-term follow-up shows the importance of surgical resection. Surgery has a role in diagnosis too.This tumor is rare, especially in pediatric patients. Although surgical resection has impact in the long-term follow up, surgical treatment should be tailored depending on tumor resectability for each patient.http://www.sciencedirect.com/science/article/pii/S2213576622002731Epstein- barr vírusSmoth muscle tumorImmunosuppresion |
| spellingShingle | Juliana Antinarelli Norberto da Silva Patricio Cieri Alexandre Alberto Barros Duarte Fernanda Kelly Marques de Souza Eliana Maria Monteiro Caran Maria Teresa Alves de Seixas Paola de La Iglesia Niveyro Paula A. Coccia Pablo Lobos Simone de Campos Vieira Abib Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients Journal of Pediatric Surgery Case Reports Epstein- barr vírus Smoth muscle tumor Immunosuppresion |
| title | Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients |
| title_full | Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients |
| title_fullStr | Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients |
| title_full_unstemmed | Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients |
| title_short | Smooth muscle tumor associated with Epstein Barr-virus in pediatric patients |
| title_sort | smooth muscle tumor associated with epstein barr virus in pediatric patients |
| topic | Epstein- barr vírus Smoth muscle tumor Immunosuppresion |
| url | http://www.sciencedirect.com/science/article/pii/S2213576622002731 |
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