The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
Background Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2021-04-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731311 |
| _version_ | 1831715349099184128 |
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| author | Veronica Mugarab-Samedi Michelle D. Ryan Essa Hamdan Al Awad Adel Elsharkawy |
| author_facet | Veronica Mugarab-Samedi Michelle D. Ryan Essa Hamdan Al Awad Adel Elsharkawy |
| author_sort | Veronica Mugarab-Samedi |
| collection | DOAJ |
| description | Background Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment.
Case Presentation We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity.
Conclusion A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation. |
| first_indexed | 2024-12-21T00:18:08Z |
| format | Article |
| id | doaj.art-ae274f10e31d4a94897fd7fd68d79159 |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-21T00:18:08Z |
| publishDate | 2021-04-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-ae274f10e31d4a94897fd7fd68d791592022-12-21T19:22:11ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052021-04-011102e102e10410.1055/s-0041-1731311The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)Veronica Mugarab-Samedi0Michelle D. Ryan1Essa Hamdan Al Awad2Adel Elsharkawy3Department of Pediatrics, University of Saskatchewan, Saskatoon, CanadaSection of Neonatology, University of Calgary, Calgary, Alberta, CanadaSection of Neonatology, University of Calgary, Calgary, Alberta, CanadaSection of Neonatology, University of Calgary, Calgary, Alberta, CanadaBackground Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment. Case Presentation We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity. Conclusion A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731311neonatal hemochromatosisintravenous immunoglobulinprenatal treatmentcase report |
| spellingShingle | Veronica Mugarab-Samedi Michelle D. Ryan Essa Hamdan Al Awad Adel Elsharkawy The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) American Journal of Perinatology Reports neonatal hemochromatosis intravenous immunoglobulin prenatal treatment case report |
| title | The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) |
| title_full | The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) |
| title_fullStr | The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) |
| title_full_unstemmed | The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) |
| title_short | The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) |
| title_sort | effect of prenatal and postnatal treatment with intravenous immunoglobulin on severity of neonatal hemochromatosis the tale of two brothers case report |
| topic | neonatal hemochromatosis intravenous immunoglobulin prenatal treatment case report |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731311 |
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