DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18304-z |
| _version_ | 1818845865799843840 |
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| author | Xiaozhou Li Jian Pan Huiling Li Guangdi Li Xiangfeng Liu Bohao Liu Zhibiao He Zhengyu Peng Hongliang Zhang Yijian Li Xudong Xiang Xiangping Chai Yunchang Yuan Peilin Zheng Feng Liu Dongshan Zhang |
| author_facet | Xiaozhou Li Jian Pan Huiling Li Guangdi Li Xiangfeng Liu Bohao Liu Zhibiao He Zhengyu Peng Hongliang Zhang Yijian Li Xudong Xiang Xiangping Chai Yunchang Yuan Peilin Zheng Feng Liu Dongshan Zhang |
| author_sort | Xiaozhou Li |
| collection | DOAJ |
| description | DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis. |
| first_indexed | 2024-12-19T05:36:27Z |
| format | Article |
| id | doaj.art-ae280dd3997a4201992ebb94a4b819a9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:36:27Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ae280dd3997a4201992ebb94a4b819a92022-12-21T20:34:08ZengNature PortfolioNature Communications2041-17232020-09-0111111310.1038/s41467-020-18304-zDsbA-L mediated renal tubulointerstitial fibrosis in UUO miceXiaozhou Li0Jian Pan1Huiling Li2Guangdi Li3Xiangfeng Liu4Bohao Liu5Zhibiao He6Zhengyu Peng7Hongliang Zhang8Yijian Li9Xudong Xiang10Xiangping Chai11Yunchang Yuan12Peilin Zheng13Feng Liu14Dongshan Zhang15Department of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South UniversityDepartment of Trauma center, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Urinary Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Chest Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Endocrinology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and TechnologyDepartment of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.https://doi.org/10.1038/s41467-020-18304-z |
| spellingShingle | Xiaozhou Li Jian Pan Huiling Li Guangdi Li Xiangfeng Liu Bohao Liu Zhibiao He Zhengyu Peng Hongliang Zhang Yijian Li Xudong Xiang Xiangping Chai Yunchang Yuan Peilin Zheng Feng Liu Dongshan Zhang DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice Nature Communications |
| title | DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice |
| title_full | DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice |
| title_fullStr | DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice |
| title_full_unstemmed | DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice |
| title_short | DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice |
| title_sort | dsba l mediated renal tubulointerstitial fibrosis in uuo mice |
| url | https://doi.org/10.1038/s41467-020-18304-z |
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