Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life
We assessed the risk of any and site-specific cancers in a case-control study of parous women living in northeast Scotland in relation to: total number of pregnancies, cumulative time pregnant, age at first delivery and interpregnancy interval. We analysed 6430 women with cancer and 6430 age-matched...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/15/3731 |
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| author | Zahra Pasdar Neil W. Scott Lisa Iversen Philip C. Hannaford Phyo Kyaw Myint Sohinee Bhattacharya |
| author_facet | Zahra Pasdar Neil W. Scott Lisa Iversen Philip C. Hannaford Phyo Kyaw Myint Sohinee Bhattacharya |
| author_sort | Zahra Pasdar |
| collection | DOAJ |
| description | We assessed the risk of any and site-specific cancers in a case-control study of parous women living in northeast Scotland in relation to: total number of pregnancies, cumulative time pregnant, age at first delivery and interpregnancy interval. We analysed 6430 women with cancer and 6430 age-matched controls. After adjustment for confounders, women with increasing number of pregnancies had similar odds of cancer diagnosis as women with only one pregnancy. The adjusted odds of cancer diagnosis were no higher in women with cumulative pregnancy time 50–150 weeks compared to those pregnant ≤ 50 weeks. Compared with women who had their first delivery at or before 20 years of age, the adjusted odds ratio (AOR) among those aged 21–25 years was 0.81, 95% CI 0.74, 0.88; 26–30 years AOR 0.77, 95% CI 0.69, 0.86; >30 years AOR 0.63, 95% CI 0.55, 0.73. After adjustment, the odds of having any cancer were higher in women who had an inter-pregnancy interval >3 years compared to those with no subsequent pregnancy (AOR 1.17, 95% CI 1.05, 1.30). Older age at first pregnancy was associated with increased risk of breast and gastrointestinal cancer, and reduced risk of invasive cervical, carcinoma in situ of the cervix and respiratory cancer. |
| first_indexed | 2024-03-10T09:18:07Z |
| format | Article |
| id | doaj.art-ae294022ccb9416ebfbf39474ce741b5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:18:07Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ae294022ccb9416ebfbf39474ce741b52023-11-22T05:26:51ZengMDPI AGCancers2072-66942021-07-011315373110.3390/cancers13153731Reproductive Pattern of Parous Women and the Risk of Cancer in Later LifeZahra Pasdar0Neil W. Scott1Lisa Iversen2Philip C. Hannaford3Phyo Kyaw Myint4Sohinee Bhattacharya5School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UKMedical Statistics Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKAcademic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKAcademic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKAgeing Clinical & Experimental Research Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKAberdeen Centre for Women’s Health Research, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZL, UKWe assessed the risk of any and site-specific cancers in a case-control study of parous women living in northeast Scotland in relation to: total number of pregnancies, cumulative time pregnant, age at first delivery and interpregnancy interval. We analysed 6430 women with cancer and 6430 age-matched controls. After adjustment for confounders, women with increasing number of pregnancies had similar odds of cancer diagnosis as women with only one pregnancy. The adjusted odds of cancer diagnosis were no higher in women with cumulative pregnancy time 50–150 weeks compared to those pregnant ≤ 50 weeks. Compared with women who had their first delivery at or before 20 years of age, the adjusted odds ratio (AOR) among those aged 21–25 years was 0.81, 95% CI 0.74, 0.88; 26–30 years AOR 0.77, 95% CI 0.69, 0.86; >30 years AOR 0.63, 95% CI 0.55, 0.73. After adjustment, the odds of having any cancer were higher in women who had an inter-pregnancy interval >3 years compared to those with no subsequent pregnancy (AOR 1.17, 95% CI 1.05, 1.30). Older age at first pregnancy was associated with increased risk of breast and gastrointestinal cancer, and reduced risk of invasive cervical, carcinoma in situ of the cervix and respiratory cancer.https://www.mdpi.com/2072-6694/13/15/3731pregnancyreproductive factorscancer |
| spellingShingle | Zahra Pasdar Neil W. Scott Lisa Iversen Philip C. Hannaford Phyo Kyaw Myint Sohinee Bhattacharya Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life Cancers pregnancy reproductive factors cancer |
| title | Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life |
| title_full | Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life |
| title_fullStr | Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life |
| title_full_unstemmed | Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life |
| title_short | Reproductive Pattern of Parous Women and the Risk of Cancer in Later Life |
| title_sort | reproductive pattern of parous women and the risk of cancer in later life |
| topic | pregnancy reproductive factors cancer |
| url | https://www.mdpi.com/2072-6694/13/15/3731 |
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