Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the primary form of liver cancer. It causes ∼ 800 000 deaths per year, which is expected to increase due to increasing rates of obesity and metabolic dysfunction associated steatotic liver disease (MASLD). Current therapies include immune checkpoint inhibitors, tyro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-12-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338231219434 |
| _version_ | 1797393082654654464 |
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| author | Sheraz Ahmad Bhat PhD Zeenat Farooq PhD Hagar Ismail BS Irene Corona-Avila BS Md. Wasim Khan PhD |
| author_facet | Sheraz Ahmad Bhat PhD Zeenat Farooq PhD Hagar Ismail BS Irene Corona-Avila BS Md. Wasim Khan PhD |
| author_sort | Sheraz Ahmad Bhat PhD |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the primary form of liver cancer. It causes ∼ 800 000 deaths per year, which is expected to increase due to increasing rates of obesity and metabolic dysfunction associated steatotic liver disease (MASLD). Current therapies include immune checkpoint inhibitors, tyrosine kinase inhibitors, and monoclonal antibodies, but these therapies are not satisfactorily effective and often come with multiple side effects and recurrences. Metabolic reprogramming plays a significant role in HCC progression and is often conserved between tumor types. Thus, targeting rewired metabolic pathways could provide an attractive option for targeting tumor cells alone or in conjunction with existing treatments. Therefore, there is an urgent need to identify novel targets involved in cancer-mediated metabolic reprogramming in HCC. In this review, we provide an overview of molecular rewiring and metabolic reprogramming of glucose metabolism in HCC to understand better the concepts that might widen the therapeutic window against this deadly cancer. |
| first_indexed | 2024-03-08T23:58:00Z |
| format | Article |
| id | doaj.art-ae2a16a95f9c44b1b2c65e35b658b288 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-03-08T23:58:00Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-ae2a16a95f9c44b1b2c65e35b658b2882023-12-13T00:03:20ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382023-12-012210.1177/15330338231219434Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular CarcinomaSheraz Ahmad Bhat PhD0Zeenat Farooq PhD1Hagar Ismail BS2Irene Corona-Avila BS3Md. Wasim Khan PhD4 Sri Pratap College, Cluster University Srinagar, Srinagar, Jammu & Kashmir, India Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, , Chicago, IL, USA Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, , Chicago, IL, USA Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, , Chicago, IL, USA Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, , Chicago, IL, USAHepatocellular carcinoma (HCC) is the primary form of liver cancer. It causes ∼ 800 000 deaths per year, which is expected to increase due to increasing rates of obesity and metabolic dysfunction associated steatotic liver disease (MASLD). Current therapies include immune checkpoint inhibitors, tyrosine kinase inhibitors, and monoclonal antibodies, but these therapies are not satisfactorily effective and often come with multiple side effects and recurrences. Metabolic reprogramming plays a significant role in HCC progression and is often conserved between tumor types. Thus, targeting rewired metabolic pathways could provide an attractive option for targeting tumor cells alone or in conjunction with existing treatments. Therefore, there is an urgent need to identify novel targets involved in cancer-mediated metabolic reprogramming in HCC. In this review, we provide an overview of molecular rewiring and metabolic reprogramming of glucose metabolism in HCC to understand better the concepts that might widen the therapeutic window against this deadly cancer.https://doi.org/10.1177/15330338231219434 |
| spellingShingle | Sheraz Ahmad Bhat PhD Zeenat Farooq PhD Hagar Ismail BS Irene Corona-Avila BS Md. Wasim Khan PhD Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma Technology in Cancer Research & Treatment |
| title | Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma |
| title_full | Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma |
| title_fullStr | Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma |
| title_full_unstemmed | Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma |
| title_short | Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma |
| title_sort | unraveling the sweet secrets of hcc glucometabolic rewiring in hepatocellular carcinoma |
| url | https://doi.org/10.1177/15330338231219434 |
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