Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving the overall survival of LM patients. Cerebros...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1079796/full |
| _version_ | 1797979955267633152 |
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| author | Hanbin Wang Hanbin Wang Luxuan Wang Chuan Fang Chuan Fang Chuan Fang Chuan Fang Chunhui Li Chunhui Li Lijian Zhang Lijian Zhang Lijian Zhang Lijian Zhang |
| author_facet | Hanbin Wang Hanbin Wang Luxuan Wang Chuan Fang Chuan Fang Chuan Fang Chuan Fang Chunhui Li Chunhui Li Lijian Zhang Lijian Zhang Lijian Zhang Lijian Zhang |
| author_sort | Hanbin Wang |
| collection | DOAJ |
| description | BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving the overall survival of LM patients. Cerebrospinal fluid (CSF) biopsy technology has attracted widespread attention for its diagnostic value in diverse cancers, including LM. We summarized studies to compare the potential diagnostic value of CSF liquid biopsy techniques in BM patients with meta-analysis.MethodsThe study protocol was prospectively registered in PROSPERO, registration number CRD42022373263. We obtained the literature on liquid biopsy for BM from 7 databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and Wanfang Data knowledge service platform). Then, a systematic review of those studies was performed according to PRISMA criteria.ResultsNine publications have been obtained, and we found CSF liquid biopsy techniques to be more suitable for diagnosing LM. We analyzed the sensitivity, specificity, and area under the curve (AUC) of CSF liquid biopsy. The overall sensitivity, specificity, and AUC of CSF liquid biopsy in the diagnosis of LM were 0.65 (95% CI: 0.48 - 0.79), 0.70 (95% CI: 0.50 - 0.86), and 0.69, respectively. Then, we compared the diagnostic advantages of CSF liquid biopsy techniques and CSF cytology in LM. The results show that CSF liquid biopsy is superior to CSF cytology in LM diagnosis.ConclusionsOur meta-analysis suggested that CSF liquid biopsy is more suitable for LM diagnosis and has higher accuracy than CSF cytology. |
| first_indexed | 2024-04-11T05:48:09Z |
| format | Article |
| id | doaj.art-ae2a325bb56f444e8459a7e662b9013e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T05:48:09Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ae2a325bb56f444e8459a7e662b9013e2022-12-22T04:42:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10797961079796Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysisHanbin Wang0Hanbin Wang1Luxuan Wang2Chuan Fang3Chuan Fang4Chuan Fang5Chuan Fang6Chunhui Li7Chunhui Li8Lijian Zhang9Lijian Zhang10Lijian Zhang11Lijian Zhang12Clinical Medicine College, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaDepartment of Neurological Function Examination, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaClinical Medicine College, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaPostdoctoral Research Station of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaKey Laboratory of Precise Diagnosis and Treatment of Glioma in Hebei Province, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaClinical Medicine College, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaClinical Medicine College, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaPostdoctoral Research Station of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaKey Laboratory of Precise Diagnosis and Treatment of Glioma in Hebei Province, Affiliated Hospital of Hebei University, Hebei University, Baoding, Hebei, ChinaBackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving the overall survival of LM patients. Cerebrospinal fluid (CSF) biopsy technology has attracted widespread attention for its diagnostic value in diverse cancers, including LM. We summarized studies to compare the potential diagnostic value of CSF liquid biopsy techniques in BM patients with meta-analysis.MethodsThe study protocol was prospectively registered in PROSPERO, registration number CRD42022373263. We obtained the literature on liquid biopsy for BM from 7 databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and Wanfang Data knowledge service platform). Then, a systematic review of those studies was performed according to PRISMA criteria.ResultsNine publications have been obtained, and we found CSF liquid biopsy techniques to be more suitable for diagnosing LM. We analyzed the sensitivity, specificity, and area under the curve (AUC) of CSF liquid biopsy. The overall sensitivity, specificity, and AUC of CSF liquid biopsy in the diagnosis of LM were 0.65 (95% CI: 0.48 - 0.79), 0.70 (95% CI: 0.50 - 0.86), and 0.69, respectively. Then, we compared the diagnostic advantages of CSF liquid biopsy techniques and CSF cytology in LM. The results show that CSF liquid biopsy is superior to CSF cytology in LM diagnosis.ConclusionsOur meta-analysis suggested that CSF liquid biopsy is more suitable for LM diagnosis and has higher accuracy than CSF cytology.https://www.frontiersin.org/articles/10.3389/fonc.2022.1079796/fullbrain parenchymal metastasesliquid biopsyleptomeningeal metastasesdiagnosismeta-analysis |
| spellingShingle | Hanbin Wang Hanbin Wang Luxuan Wang Chuan Fang Chuan Fang Chuan Fang Chuan Fang Chunhui Li Chunhui Li Lijian Zhang Lijian Zhang Lijian Zhang Lijian Zhang Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis Frontiers in Oncology brain parenchymal metastases liquid biopsy leptomeningeal metastases diagnosis meta-analysis |
| title | Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis |
| title_full | Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis |
| title_fullStr | Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis |
| title_full_unstemmed | Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis |
| title_short | Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis |
| title_sort | comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases a systematic review and meta analysis |
| topic | brain parenchymal metastases liquid biopsy leptomeningeal metastases diagnosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1079796/full |
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