Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis
Aida Ahmed Abdelmaksoud,1 Asmaa Nafady,2 Shamardan Ezzeldin Sayed Bazeed,3 Mahmoud Khalefa,4 Mahmoud K Elsamman,5 Mennatallah Ali Abdelrhman Sayed,6 Heba Mohammad Qubaisy,7 Ali A Ghweil,3 Zaki F Aref1,8 1ENT, South Valley University, Qena, Egypt; 2Clinical and Chemical Pathology, South Valley Univer...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-09-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/lactoferrin-versus-long-acting-penicillin-in-reducing-elevated-anti-st-peer-reviewed-fulltext-article-IDR |
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| author | Ahmed Abdelmaksoud A Nafady A Ezzeldin Sayed Bazeed S Khalefa M Elsamman MK Abdelrhman Sayed MA Qubaisy HM Ghweil AA Aref ZF |
| author_facet | Ahmed Abdelmaksoud A Nafady A Ezzeldin Sayed Bazeed S Khalefa M Elsamman MK Abdelrhman Sayed MA Qubaisy HM Ghweil AA Aref ZF |
| author_sort | Ahmed Abdelmaksoud A |
| collection | DOAJ |
| description | Aida Ahmed Abdelmaksoud,1 Asmaa Nafady,2 Shamardan Ezzeldin Sayed Bazeed,3 Mahmoud Khalefa,4 Mahmoud K Elsamman,5 Mennatallah Ali Abdelrhman Sayed,6 Heba Mohammad Qubaisy,7 Ali A Ghweil,3 Zaki F Aref1,8 1ENT, South Valley University, Qena, Egypt; 2Clinical and Chemical Pathology, South Valley University, Qena, Egypt; 3Tropical Medicine and Gastroenterology, South Valley University, Qena, Egypt; 4ENT, Faculty of Medicine, Aswan University, Aswan, Egypt; 5Internal Medicine, Sohag University, Sohag, Egypt; 6King Salman International University, Sharm ElSheikh, Egypt; 7Pediatrics, South Valley University, Qena, Egypt; 8Department and Institution, ENT Department, Clinical and Chemical Chemistry Department Faculty of Medicine, South Valley University, Qena, EgyptCorrespondence: Asmaa Nafady, Clinical and Chemical Pathology, Qena Faculty of Medicine, South Valley University, Qena, Egypt, Tel +1069587945, Fax +20 965 337 571, Email asmaa_nafadyhn@yahoo.com; asmaa.nafady@med.svu.edu.egBackground: Beta-Hemolytic streptococci are the most frequent bacteria causing tonsillitis. Lactoferrin may play a role in the treatment of chronic tonsillitis due to its direct antimicrobial activity.Objective: To assess the possible role of lactoferrin in reduction of raised serum Anti-Streptolysin O Titer (ASOT) in cases of chronic tonsillopharyngitis in comparison to long acting penicillin.Methods: This study included 117 children with tonsillopharyngitis with high ASOT randomly divided into three groups; group 1 treated with lactoferrin, group 2 treated with long acting penicillin and group 3 treated with both drugs. For all patients ASOT was measured after three and six months of starting treatment.Results: This study included 60 males and 57 females with the mean age (8.5 ± 2.4). There is statistically significant reduction in ASOT in all groups after three months of treatment. ASOT after 3 months was significantly lower in group1 (370± 440) and group 3 (350± 450) in comparison to group 2 (420± 560) with p value 0.02, 0.004, respectively, with no significant difference in comparing group 1 to group 3 p value 0.4. Also, ASO titre after 6 months was significantly lower in group1 (350± 420) and group 3 (340± 440) in comparison to group 2 (420± 550) with p value 0.02, 0.007, respectively, with no significant difference in comparing group 1 to group 3 p value 0.5. In comparing ASOT at three months and six months of treatment in the three studied groups; it decreased by 2% in group 1, and 1.6% in group 3 and no change in group 2.Conclusion: Lactoferrin alone or in combination with long acting penicillin is safe and more effective than long acting penicillin alone in reducing ASOT. Treatment for six months with lactoferrin alone or in combination with long acting penicillin could offer a better response.Keywords: lactoferrin, long-acting penicillin, anti-streptolysin O titer, tonsillopharyngitis |
| first_indexed | 2024-04-12T23:45:09Z |
| format | Article |
| id | doaj.art-ae2d12d3868147e4b24273e3670d29c7 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-12T23:45:09Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-ae2d12d3868147e4b24273e3670d29c72022-12-22T03:11:53ZengDove Medical PressInfection and Drug Resistance1178-69732022-09-01Volume 155257526377998Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of TonsillopharyngitisAhmed Abdelmaksoud ANafady AEzzeldin Sayed Bazeed SKhalefa MElsamman MKAbdelrhman Sayed MAQubaisy HMGhweil AAAref ZFAida Ahmed Abdelmaksoud,1 Asmaa Nafady,2 Shamardan Ezzeldin Sayed Bazeed,3 Mahmoud Khalefa,4 Mahmoud K Elsamman,5 Mennatallah Ali Abdelrhman Sayed,6 Heba Mohammad Qubaisy,7 Ali A Ghweil,3 Zaki F Aref1,8 1ENT, South Valley University, Qena, Egypt; 2Clinical and Chemical Pathology, South Valley University, Qena, Egypt; 3Tropical Medicine and Gastroenterology, South Valley University, Qena, Egypt; 4ENT, Faculty of Medicine, Aswan University, Aswan, Egypt; 5Internal Medicine, Sohag University, Sohag, Egypt; 6King Salman International University, Sharm ElSheikh, Egypt; 7Pediatrics, South Valley University, Qena, Egypt; 8Department and Institution, ENT Department, Clinical and Chemical Chemistry Department Faculty of Medicine, South Valley University, Qena, EgyptCorrespondence: Asmaa Nafady, Clinical and Chemical Pathology, Qena Faculty of Medicine, South Valley University, Qena, Egypt, Tel +1069587945, Fax +20 965 337 571, Email asmaa_nafadyhn@yahoo.com; asmaa.nafady@med.svu.edu.egBackground: Beta-Hemolytic streptococci are the most frequent bacteria causing tonsillitis. Lactoferrin may play a role in the treatment of chronic tonsillitis due to its direct antimicrobial activity.Objective: To assess the possible role of lactoferrin in reduction of raised serum Anti-Streptolysin O Titer (ASOT) in cases of chronic tonsillopharyngitis in comparison to long acting penicillin.Methods: This study included 117 children with tonsillopharyngitis with high ASOT randomly divided into three groups; group 1 treated with lactoferrin, group 2 treated with long acting penicillin and group 3 treated with both drugs. For all patients ASOT was measured after three and six months of starting treatment.Results: This study included 60 males and 57 females with the mean age (8.5 ± 2.4). There is statistically significant reduction in ASOT in all groups after three months of treatment. ASOT after 3 months was significantly lower in group1 (370± 440) and group 3 (350± 450) in comparison to group 2 (420± 560) with p value 0.02, 0.004, respectively, with no significant difference in comparing group 1 to group 3 p value 0.4. Also, ASO titre after 6 months was significantly lower in group1 (350± 420) and group 3 (340± 440) in comparison to group 2 (420± 550) with p value 0.02, 0.007, respectively, with no significant difference in comparing group 1 to group 3 p value 0.5. In comparing ASOT at three months and six months of treatment in the three studied groups; it decreased by 2% in group 1, and 1.6% in group 3 and no change in group 2.Conclusion: Lactoferrin alone or in combination with long acting penicillin is safe and more effective than long acting penicillin alone in reducing ASOT. Treatment for six months with lactoferrin alone or in combination with long acting penicillin could offer a better response.Keywords: lactoferrin, long-acting penicillin, anti-streptolysin O titer, tonsillopharyngitishttps://www.dovepress.com/lactoferrin-versus-long-acting-penicillin-in-reducing-elevated-anti-st-peer-reviewed-fulltext-article-IDRlactoferrinlong-acting penicillinanti-streptolysin o titertonsillopharyngitis |
| spellingShingle | Ahmed Abdelmaksoud A Nafady A Ezzeldin Sayed Bazeed S Khalefa M Elsamman MK Abdelrhman Sayed MA Qubaisy HM Ghweil AA Aref ZF Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis Infection and Drug Resistance lactoferrin long-acting penicillin anti-streptolysin o titer tonsillopharyngitis |
| title | Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis |
| title_full | Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis |
| title_fullStr | Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis |
| title_full_unstemmed | Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis |
| title_short | Lactoferrin versus Long-Acting Penicillin in Reducing Elevated Anti-Streptolysin O Titer in Cases of Tonsillopharyngitis |
| title_sort | lactoferrin versus long acting penicillin in reducing elevated anti streptolysin o titer in cases of tonsillopharyngitis |
| topic | lactoferrin long-acting penicillin anti-streptolysin o titer tonsillopharyngitis |
| url | https://www.dovepress.com/lactoferrin-versus-long-acting-penicillin-in-reducing-elevated-anti-st-peer-reviewed-fulltext-article-IDR |
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