Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study
<p>Abstract</p> <p>Background</p> <p>Phytanic acid produced in ruminants from chlorophyll may have preventive effects on the metabolic syndrome, partly due to its reported RXR and PPAR- α agonist activity. Milk from cows fed increased levels of green plant material, con...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-06-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/10/1/95 |
| _version_ | 1818664973514047488 |
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| author | Drachmann Tue Petersen Rikke A Jensen Søren K Raff Marianne Hellgren Lars I Werner Louise B Tholstrup Tine |
| author_facet | Drachmann Tue Petersen Rikke A Jensen Søren K Raff Marianne Hellgren Lars I Werner Louise B Tholstrup Tine |
| author_sort | Drachmann Tue |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Phytanic acid produced in ruminants from chlorophyll may have preventive effects on the metabolic syndrome, partly due to its reported RXR and PPAR- α agonist activity. Milk from cows fed increased levels of green plant material, contains increased phytanic acid concentrations, but it is unknown to what extent minor increases in phytanic acid content in dairy fat leads to higher circulating levels of phytanic acid in plasma of the consumers.</p> <p>Objective</p> <p>To investigate if cow feeding regimes affects concentration of plasma phytanic acid and risk markers of the metabolic syndrome in human.</p> <p>Design</p> <p>In a double-blind, randomized, 4 wk, parallel intervention study 14 healthy young subjects were given 45 g milk fat/d from test butter and cheese with 0.24 wt% phytanic acid or a control diet with 0.13 wt% phytanic acid. Difference in phytanic acid was obtained by feeding roughage with low or high content of chlorophyll.</p> <p>Results</p> <p>There tended to be a difference in plasma phytanic acid (P = 0.0730) concentration after the dietary intervention. Plasma phytanic acid increased significantly within both groups with the highest increase in control group (24%) compared to phytanic acid group (15%). There were no significant effects of phytanic acid on risk markers for the metabolic syndrome.</p> <p>Conclusions</p> <p>The results indicate that increased intake of dairy fat modify the plasma phytanic acid concentration, regardless of cows feeding regime and the minor difference in dietary phytanic acid. Whether the phytanic acid has potential to affects the risk markers of the metabolic syndrome in human still remain to be elucidated.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01343576">NCT01343576</a></p> |
| first_indexed | 2024-12-17T05:41:15Z |
| format | Article |
| id | doaj.art-ae30c058f00b43aba9292c5f2dd0dae1 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-17T05:41:15Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-ae30c058f00b43aba9292c5f2dd0dae12022-12-21T22:01:26ZengBMCLipids in Health and Disease1476-511X2011-06-011019510.1186/1476-511X-10-95Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled studyDrachmann TuePetersen Rikke AJensen Søren KRaff MarianneHellgren Lars IWerner Louise BTholstrup Tine<p>Abstract</p> <p>Background</p> <p>Phytanic acid produced in ruminants from chlorophyll may have preventive effects on the metabolic syndrome, partly due to its reported RXR and PPAR- α agonist activity. Milk from cows fed increased levels of green plant material, contains increased phytanic acid concentrations, but it is unknown to what extent minor increases in phytanic acid content in dairy fat leads to higher circulating levels of phytanic acid in plasma of the consumers.</p> <p>Objective</p> <p>To investigate if cow feeding regimes affects concentration of plasma phytanic acid and risk markers of the metabolic syndrome in human.</p> <p>Design</p> <p>In a double-blind, randomized, 4 wk, parallel intervention study 14 healthy young subjects were given 45 g milk fat/d from test butter and cheese with 0.24 wt% phytanic acid or a control diet with 0.13 wt% phytanic acid. Difference in phytanic acid was obtained by feeding roughage with low or high content of chlorophyll.</p> <p>Results</p> <p>There tended to be a difference in plasma phytanic acid (P = 0.0730) concentration after the dietary intervention. Plasma phytanic acid increased significantly within both groups with the highest increase in control group (24%) compared to phytanic acid group (15%). There were no significant effects of phytanic acid on risk markers for the metabolic syndrome.</p> <p>Conclusions</p> <p>The results indicate that increased intake of dairy fat modify the plasma phytanic acid concentration, regardless of cows feeding regime and the minor difference in dietary phytanic acid. Whether the phytanic acid has potential to affects the risk markers of the metabolic syndrome in human still remain to be elucidated.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01343576">NCT01343576</a></p>http://www.lipidworld.com/content/10/1/95Phytanic acidcow-feeding regimeabsorptionfatty acidtotal cholesterolLDL cholesterolHDL cholesterolC-reactive proteininsulinglucose |
| spellingShingle | Drachmann Tue Petersen Rikke A Jensen Søren K Raff Marianne Hellgren Lars I Werner Louise B Tholstrup Tine Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study Lipids in Health and Disease Phytanic acid cow-feeding regime absorption fatty acid total cholesterol LDL cholesterol HDL cholesterol C-reactive protein insulin glucose |
| title | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study |
| title_full | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study |
| title_fullStr | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study |
| title_full_unstemmed | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study |
| title_short | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study |
| title_sort | effect of dairy fat on plasma phytanic acid in healthy volunteers a randomized controlled study |
| topic | Phytanic acid cow-feeding regime absorption fatty acid total cholesterol LDL cholesterol HDL cholesterol C-reactive protein insulin glucose |
| url | http://www.lipidworld.com/content/10/1/95 |
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