Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling

Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling

THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC) by its specific blocker, amiloride. Experime...

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Bibliographic Details
Main Authors: Maria Mernea, Roxana Ștefania Ulăreanu, Dana Cucu, Jasim Hafedh Al-Saedi, Cristian-Emilian Pop, Sergiu Fendrihan, Giorgiana Diana Carmen Anghelescu, Dan Florin Mihăilescu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
THz spectroscopy
ion channel
epithelial sodium channel
amiloride binding
spectra simulation
Online Access:https://www.mdpi.com/1420-3049/27/10/3271

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