Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis
Objective: Ephedra asarum aconite decoction is used in the clinical treatment of allergic rhinitis. We investigated the effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis and in activated T cells in vitro. Methods: Animal models of simple and com...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754817301230 |
| _version_ | 1827847065498025984 |
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| author | Min Liu Wenting Ji Liye Pan Qingguo Wang Gang Zhou |
| author_facet | Min Liu Wenting Ji Liye Pan Qingguo Wang Gang Zhou |
| author_sort | Min Liu |
| collection | DOAJ |
| description | Objective: Ephedra asarum aconite decoction is used in the clinical treatment of allergic rhinitis. We investigated the effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis and in activated T cells in vitro.
Methods: Animal models of simple and compound kidney yang deficiency types of allergic rhinitis were treated with ephedra asarum aconite decoction to observe the efficacy of this traditional Chinese medicine formula on allergic symptoms, serum cytokines, and tissue RNA levels. We also cultured and activated T cells from the mouse. After treatment with ephedra asarum aconite decoction, we tested the proliferation and differentiation of T cells.
Results: Ephedra asarum aconite decoction relieved allergy symptoms in both types of animal models, and was more effective in the compound kidney yang deficiency model. In addition to its anti-allergic efficacy, ephedra asarum aconite decoction significantly improved the health status of animals in the compound kidney yang deficiency groups, significantly made their bodyweight rising up, and significantly increased the T-bet mRNA/GATA-3 mRNA ratio. Moreover, ephedra asarum aconite decoction promoted the proliferation of activated T cells and inhibited the differentiation to Th2 cells in vitro.
Conclusions: Ephedra asarum aconite decoction regulates the balance of Th1/Th2 to ameliorate allergic conditions. |
| first_indexed | 2024-03-12T09:24:34Z |
| format | Article |
| id | doaj.art-ae328ccff7ba47e3b1dc5bb66b9d1971 |
| institution | Directory Open Access Journal |
| issn | 2095-7548 |
| language | English |
| last_indexed | 2024-03-12T09:24:34Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj.art-ae328ccff7ba47e3b1dc5bb66b9d19712023-09-02T14:18:50ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482017-07-014326127110.1016/j.jtcms.2017.07.015Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitisMin LiuWenting JiLiye PanQingguo WangGang ZhouObjective: Ephedra asarum aconite decoction is used in the clinical treatment of allergic rhinitis. We investigated the effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis and in activated T cells in vitro. Methods: Animal models of simple and compound kidney yang deficiency types of allergic rhinitis were treated with ephedra asarum aconite decoction to observe the efficacy of this traditional Chinese medicine formula on allergic symptoms, serum cytokines, and tissue RNA levels. We also cultured and activated T cells from the mouse. After treatment with ephedra asarum aconite decoction, we tested the proliferation and differentiation of T cells. Results: Ephedra asarum aconite decoction relieved allergy symptoms in both types of animal models, and was more effective in the compound kidney yang deficiency model. In addition to its anti-allergic efficacy, ephedra asarum aconite decoction significantly improved the health status of animals in the compound kidney yang deficiency groups, significantly made their bodyweight rising up, and significantly increased the T-bet mRNA/GATA-3 mRNA ratio. Moreover, ephedra asarum aconite decoction promoted the proliferation of activated T cells and inhibited the differentiation to Th2 cells in vitro. Conclusions: Ephedra asarum aconite decoction regulates the balance of Th1/Th2 to ameliorate allergic conditions.http://www.sciencedirect.com/science/article/pii/S2095754817301230Ephedra asarum aconite decoctionTh1/Th2Allergic rhinitisGuinea pigs |
| spellingShingle | Min Liu Wenting Ji Liye Pan Qingguo Wang Gang Zhou Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis Journal of Traditional Chinese Medical Sciences Ephedra asarum aconite decoction Th1/Th2 Allergic rhinitis Guinea pigs |
| title | Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis |
| title_full | Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis |
| title_fullStr | Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis |
| title_full_unstemmed | Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis |
| title_short | Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis |
| title_sort | effects of ephedra asarum aconite decoction on th1 th2 balance in two animal models of allergic rhinitis |
| topic | Ephedra asarum aconite decoction Th1/Th2 Allergic rhinitis Guinea pigs |
| url | http://www.sciencedirect.com/science/article/pii/S2095754817301230 |
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