Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk
Microcrystalline cellulose is a vital ingredient in the food, pharmaceutical, and cosmetics industries. In this study, Bambara nutshell microcrystalline cellulose (BNS-MCC) was prepared by acid hydrolysis modification of Bambara nutshell alpha-cellulose pulp. The sample was subjected to sodium hydro...
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| Format: | Article |
| Language: | English |
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Nigerian Society of Physical Sciences
2022-08-01
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| Series: | African Scientific Reports |
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| Online Access: | https://asr.nsps.org.ng/index.php/asr/article/view/31 |
| _version_ | 1797326170448986112 |
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| author | E. Agboeze N. P. Ani E. O. Omeje |
| author_facet | E. Agboeze N. P. Ani E. O. Omeje |
| author_sort | E. Agboeze |
| collection | DOAJ |
| description | Microcrystalline cellulose is a vital ingredient in the food, pharmaceutical, and cosmetics industries. In this study, Bambara nutshell microcrystalline cellulose (BNS-MCC) was prepared by acid hydrolysis modification of Bambara nutshell alpha-cellulose pulp. The sample was subjected to sodium hydroxide pulping (2.0% and 17.5% NaOH respectively) and a multistage pulping treatment using 3.5% nitric acid. The analysis results showed that the pulping method was effective for substantial removal of lignin with a 14.416% yield of alpha-cellulose pulp. The organoleptic and physicochemical properties of BNS-MCC were examined. The prepared BNS-MCC powder was examined using a Scanning Electron Microscope (SEM), Fourier Transform Infrared spectroscopy (FTIR), and X-ray Diffractometer (XRD). The sample’s powder flow properties (true density, Hausner index, Carr’s index, angle of repose,
powder porosity, loss on drying, and moisture sorption capacity) were (1.216g/mL, 1.34, 25.75%, 39.80o, 64.7%, and 46.81%). The results of the analysis of the BNS-MCC compared well with commercial grades and conformed to US Pharmacopeia (USP) and British Pharmacopeia specifications. This result shows that Bambara nutshells have potential application for pharmaceutical grade cellulose production used in direct compression tableting. |
| first_indexed | 2024-03-08T06:19:41Z |
| format | Article |
| id | doaj.art-ae352f18e7d14f859acb641e944b6645 |
| institution | Directory Open Access Journal |
| issn | 2955-1625 2955-1617 |
| language | English |
| last_indexed | 2024-03-08T06:19:41Z |
| publishDate | 2022-08-01 |
| publisher | Nigerian Society of Physical Sciences |
| record_format | Article |
| series | African Scientific Reports |
| spelling | doaj.art-ae352f18e7d14f859acb641e944b66452024-02-04T08:42:42ZengNigerian Society of Physical SciencesAfrican Scientific Reports2955-16252955-16172022-08-0110311410.46481/asr.2022.1.2.3131Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) HuskE. Agboeze0N. P. Ani1E. O. Omeje2Department of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, NigeriaDepartment of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, NigeriaDepartment of Pure and Industrial Chemistry, University of Nigeria Nsukka, Enugu State, NigeriaMicrocrystalline cellulose is a vital ingredient in the food, pharmaceutical, and cosmetics industries. In this study, Bambara nutshell microcrystalline cellulose (BNS-MCC) was prepared by acid hydrolysis modification of Bambara nutshell alpha-cellulose pulp. The sample was subjected to sodium hydroxide pulping (2.0% and 17.5% NaOH respectively) and a multistage pulping treatment using 3.5% nitric acid. The analysis results showed that the pulping method was effective for substantial removal of lignin with a 14.416% yield of alpha-cellulose pulp. The organoleptic and physicochemical properties of BNS-MCC were examined. The prepared BNS-MCC powder was examined using a Scanning Electron Microscope (SEM), Fourier Transform Infrared spectroscopy (FTIR), and X-ray Diffractometer (XRD). The sample’s powder flow properties (true density, Hausner index, Carr’s index, angle of repose, powder porosity, loss on drying, and moisture sorption capacity) were (1.216g/mL, 1.34, 25.75%, 39.80o, 64.7%, and 46.81%). The results of the analysis of the BNS-MCC compared well with commercial grades and conformed to US Pharmacopeia (USP) and British Pharmacopeia specifications. This result shows that Bambara nutshells have potential application for pharmaceutical grade cellulose production used in direct compression tableting.https://asr.nsps.org.ng/index.php/asr/article/view/31extraction, characterization, bambara nut husk, microcrystalline cellulose |
| spellingShingle | E. Agboeze N. P. Ani E. O. Omeje Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk African Scientific Reports extraction, characterization, bambara nut husk, microcrystalline cellulose |
| title | Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk |
| title_full | Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk |
| title_fullStr | Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk |
| title_full_unstemmed | Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk |
| title_short | Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk |
| title_sort | extraction and characterization of pharmaceutical grade microcrystalline cellulose from bambara nut voandzeia subterranean l thousars husk |
| topic | extraction, characterization, bambara nut husk, microcrystalline cellulose |
| url | https://asr.nsps.org.ng/index.php/asr/article/view/31 |
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