Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota

Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota

Emerging evidence has linked the gut microbiota dysbiosis to transplant rejection while memory T-cells pose a threat to long-term transplant survival. However, it's unclear if the gut microbiome alters the formation and function of alloreactive memory T-cells. Here we studied the effects of ber...

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Bibliographic Details
Main Authors: Feifei Qiu, Weihui Lu, Shulin Ye, Huazhen Liu, Qiaohuang Zeng, Haiding Huang, Chun-Ling Liang, Yuchao Chen, Fang Zheng, Qunfang Zhang, Chuan-Jian Lu, Zhenhua Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
immunological tolerance
berberine
allograft rejection
memory T cell
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.646831/full

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