Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron
Abstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolytic anemia, bone marrow failure, thrombophilia. COVID‐19, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with many variants including Omicron. Methods This study collected demogr...
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.966 |
| _version_ | 1797645450170335232 |
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| author | Hui Yang Xingxing Chai Yuemin Gong Xinyu Zhang Lingling Wang Xin Zhou Xiaoyu Chen Jinge Xu Dan Xu Guangsheng He Jianyong Li |
| author_facet | Hui Yang Xingxing Chai Yuemin Gong Xinyu Zhang Lingling Wang Xin Zhou Xiaoyu Chen Jinge Xu Dan Xu Guangsheng He Jianyong Li |
| author_sort | Hui Yang |
| collection | DOAJ |
| description | Abstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolytic anemia, bone marrow failure, thrombophilia. COVID‐19, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with many variants including Omicron. Methods This study collected demographic and clinical data of 20 PNH patients with SARS‐CoV‐2 Omicron infection. Results They all were with high disease activity, and LDH level exceeded any documented since the diagnosis of PNH, and those reported in the literature for previously stable treatment with complement inhibitors. D‐dimer level elevated in 10 patients. 2 patients developed mild pulmonary artery hypertension. Glomerular filtration rate declined in 5 patients. 1 patient developed acute renal failure and underwent hemodialysis. Anemia and hemolysis were improved in 5 patients treated with eculizumab. Conclusions Hemolytic exacerbation of PNH with COVID‐19 is severe and eculizumab may be an effective treatment. |
| first_indexed | 2024-03-11T14:46:31Z |
| format | Article |
| id | doaj.art-ae36e29327904027ad2fc035dc1cdfcf |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-11T14:46:31Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-ae36e29327904027ad2fc035dc1cdfcf2023-10-30T10:50:33ZengWileyImmunity, Inflammation and Disease2050-45272023-08-01118n/an/a10.1002/iid3.966Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 OmicronHui Yang0Xingxing Chai1Yuemin Gong2Xinyu Zhang3Lingling Wang4Xin Zhou5Xiaoyu Chen6Jinge Xu7Dan Xu8Guangsheng He9Jianyong Li10Key Laboratory of Hematology of Nanjing Medical University, Department of Hematology Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing Jiangsu ChinaDepartment of Hematology The Second People's Hospital of Lianyungang Lianyungang Jiangsu ChinaKey Laboratory of Hematology of Nanjing Medical University, Department of Hematology Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing Jiangsu ChinaKey Laboratory of Hematology of Nanjing Medical University, Department of Hematology Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing Jiangsu ChinaDepartment of Hematology Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi Jiangsu ChinaDepartment of Hematology Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi Jiangsu ChinaKey Laboratory of Hematology of Nanjing Medical University, Department of Hematology Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing Jiangsu ChinaDepartment of Hematology The Second Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu ChinaDepartment of Hematology Funing People's Hospital Yancheng Jiangsu ChinaKey Laboratory of Hematology of Nanjing Medical University, Department of Hematology Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing Jiangsu ChinaKey Laboratory of Hematology of Nanjing Medical University, Department of Hematology Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing Jiangsu ChinaAbstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolytic anemia, bone marrow failure, thrombophilia. COVID‐19, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with many variants including Omicron. Methods This study collected demographic and clinical data of 20 PNH patients with SARS‐CoV‐2 Omicron infection. Results They all were with high disease activity, and LDH level exceeded any documented since the diagnosis of PNH, and those reported in the literature for previously stable treatment with complement inhibitors. D‐dimer level elevated in 10 patients. 2 patients developed mild pulmonary artery hypertension. Glomerular filtration rate declined in 5 patients. 1 patient developed acute renal failure and underwent hemodialysis. Anemia and hemolysis were improved in 5 patients treated with eculizumab. Conclusions Hemolytic exacerbation of PNH with COVID‐19 is severe and eculizumab may be an effective treatment.https://doi.org/10.1002/iid3.966complement inhibitor therapyCOVID‐19hemolysisOmicronparoxysmal nocturnal hemoglobinuria |
| spellingShingle | Hui Yang Xingxing Chai Yuemin Gong Xinyu Zhang Lingling Wang Xin Zhou Xiaoyu Chen Jinge Xu Dan Xu Guangsheng He Jianyong Li Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron Immunity, Inflammation and Disease complement inhibitor therapy COVID‐19 hemolysis Omicron paroxysmal nocturnal hemoglobinuria |
| title | Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron |
| title_full | Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron |
| title_fullStr | Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron |
| title_full_unstemmed | Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron |
| title_short | Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron |
| title_sort | severe hemolytic exacerbations of chinese pnh patients infected sars cov 2 omicron |
| topic | complement inhibitor therapy COVID‐19 hemolysis Omicron paroxysmal nocturnal hemoglobinuria |
| url | https://doi.org/10.1002/iid3.966 |
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