What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
ABSTRACT BACKGROUND: The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach. DESIGN AND SETTING: Review of SRs, conducte...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2018-10-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000500472&lng=en&tlng=en |
| _version_ | 1818197685399715840 |
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| author | Carolina de Oliveira Cruz Latorraca Rafael Leite Pacheco Ana Luiza Cabrera Martimbianco Daniela Vianna Pachito Rachel Riera |
| author_facet | Carolina de Oliveira Cruz Latorraca Rafael Leite Pacheco Ana Luiza Cabrera Martimbianco Daniela Vianna Pachito Rachel Riera |
| author_sort | Carolina de Oliveira Cruz Latorraca |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach. DESIGN AND SETTING: Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). METHODS: A broad search was conducted in the Cochrane Database of Systematic Reviews to retrieve any Cochrane SRs that assessed the efficacy and safety of cannabinoids as a therapeutic approach. The results and key characteristics of all reviews included were summarized and discussed. RESULTS: Eight SRs were included. They assessed the use of cannabinoids for the following types of conditions: neurological (two SRs), psychiatric (two SRs), rheumatological (one SR), infectious (one SR) and oncological (two SRs). There was moderate-quality evidence showing that the use of cannabinoids reduced nausea and vomiting among adults, compared with placebo. Additionally, there was moderate-quality evidence showing that there was no difference between cannabinoids and prochlorperazine regarding the number of participants who reported vomiting, in this same population. CONCLUSIONS: This review identified eight Cochrane systematic reviews that provided evidence of unknown to moderate quality regarding the use of cannabinoids as a therapeutic intervention. Further studies are still imperative for solid conclusions to be reached regarding practical recommendations. |
| first_indexed | 2024-12-12T01:53:54Z |
| format | Article |
| id | doaj.art-ae3993a0b8fb46fdb13a646e706a7154 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-12T01:53:54Z |
| publishDate | 2018-10-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-ae3993a0b8fb46fdb13a646e706a71542022-12-22T00:42:25ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602018-10-01136547247810.1590/1516-3180.2018.0313210818S1516-31802018000500472What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?Carolina de Oliveira Cruz LatorracaRafael Leite PachecoAna Luiza Cabrera MartimbiancoDaniela Vianna PachitoRachel RieraABSTRACT BACKGROUND: The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach. DESIGN AND SETTING: Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). METHODS: A broad search was conducted in the Cochrane Database of Systematic Reviews to retrieve any Cochrane SRs that assessed the efficacy and safety of cannabinoids as a therapeutic approach. The results and key characteristics of all reviews included were summarized and discussed. RESULTS: Eight SRs were included. They assessed the use of cannabinoids for the following types of conditions: neurological (two SRs), psychiatric (two SRs), rheumatological (one SR), infectious (one SR) and oncological (two SRs). There was moderate-quality evidence showing that the use of cannabinoids reduced nausea and vomiting among adults, compared with placebo. Additionally, there was moderate-quality evidence showing that there was no difference between cannabinoids and prochlorperazine regarding the number of participants who reported vomiting, in this same population. CONCLUSIONS: This review identified eight Cochrane systematic reviews that provided evidence of unknown to moderate quality regarding the use of cannabinoids as a therapeutic intervention. Further studies are still imperative for solid conclusions to be reached regarding practical recommendations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000500472&lng=en&tlng=enReview [publication type]Evidence-based medicineEvidence-based practiceCannabisCannabinoids |
| spellingShingle | Carolina de Oliveira Cruz Latorraca Rafael Leite Pacheco Ana Luiza Cabrera Martimbianco Daniela Vianna Pachito Rachel Riera What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice? São Paulo Medical Journal Review [publication type] Evidence-based medicine Evidence-based practice Cannabis Cannabinoids |
| title | What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice? |
| title_full | What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice? |
| title_fullStr | What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice? |
| title_full_unstemmed | What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice? |
| title_short | What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice? |
| title_sort | what do cochrane systematic reviews say about the use of cannabinoids in clinical practice |
| topic | Review [publication type] Evidence-based medicine Evidence-based practice Cannabis Cannabinoids |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000500472&lng=en&tlng=en |
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