Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults
Background Consensus panels regularly recommend aerobic exercise for its health‐promoting properties, due in part to presumed anti‐inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical a...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.010201 |
| _version_ | 1818288119176232960 |
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| author | Richard P. Sloan Peter A. Shapiro Paula S. McKinley Matthew Bartels Daichi Shimbo Vincenzo Lauriola Wahida Karmally Martina Pavlicova C. Jean Choi Tse‐Hwei Choo Jennifer M. Scodes Pamela Flood Kevin J. Tracey |
| author_facet | Richard P. Sloan Peter A. Shapiro Paula S. McKinley Matthew Bartels Daichi Shimbo Vincenzo Lauriola Wahida Karmally Martina Pavlicova C. Jean Choi Tse‐Hwei Choo Jennifer M. Scodes Pamela Flood Kevin J. Tracey |
| author_sort | Richard P. Sloan |
| collection | DOAJ |
| description | Background Consensus panels regularly recommend aerobic exercise for its health‐promoting properties, due in part to presumed anti‐inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti‐inflammatory effects of aerobic training elusive. Methods and Results We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)‐inducible tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), and on toll‐like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF‐α (P=0.08) and IL‐6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF‐α (51% increase, P=0.041) and IL‐6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF‐α (54% decrease, P=0.007) and IL‐6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF‐α or IL‐6. Conclusions The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise‐training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti‐inflammatory effects. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737. |
| first_indexed | 2024-12-13T01:51:19Z |
| format | Article |
| id | doaj.art-ae39fa361e334274a65cfbf20debcbfd |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T01:51:19Z |
| publishDate | 2018-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-ae39fa361e334274a65cfbf20debcbfd2022-12-22T00:03:30ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-09-0171710.1161/JAHA.118.010201Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young AdultsRichard P. Sloan0Peter A. Shapiro1Paula S. McKinley2Matthew Bartels3Daichi Shimbo4Vincenzo Lauriola5Wahida Karmally6Martina Pavlicova7C. Jean Choi8Tse‐Hwei Choo9Jennifer M. Scodes10Pamela Flood11Kevin J. Tracey12Division of Behavioral Medicine Department of Psychiatry Columbia University Medical Center New York NYDivision of Consultation/Liaison Psychiatry Department of Psychiatry Columbia University Medical Center New York NYDivision of Behavioral Medicine Department of Psychiatry Columbia University Medical Center New York NYDepartment of Rehabilitation Medicine Columbia University Medical Center New York NYDepartment of Medicine Columbia University Medical Center New York NYDivision of Behavioral Medicine Department of Psychiatry Columbia University Medical Center New York NYIrving Institute for Clinical and Translational Research Columbia University Medical Center New York NYDepartment of Biostatistics Mailman School of Public Health Columbia University Medical Center New York NYNew York State Psychiatric Institute New York NYNew York State Psychiatric Institute New York NYNew York State Psychiatric Institute New York NYDepartment of Anesthesiology Columbia University Medical Center New York NYThe Feinstein Institute for Medical Research Northwell Health Manhassett NYBackground Consensus panels regularly recommend aerobic exercise for its health‐promoting properties, due in part to presumed anti‐inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti‐inflammatory effects of aerobic training elusive. Methods and Results We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)‐inducible tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), and on toll‐like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF‐α (P=0.08) and IL‐6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF‐α (51% increase, P=0.041) and IL‐6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF‐α (54% decrease, P=0.007) and IL‐6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF‐α or IL‐6. Conclusions The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise‐training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti‐inflammatory effects. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.https://www.ahajournals.org/doi/10.1161/JAHA.118.010201clinical trialexercise traininginflammation |
| spellingShingle | Richard P. Sloan Peter A. Shapiro Paula S. McKinley Matthew Bartels Daichi Shimbo Vincenzo Lauriola Wahida Karmally Martina Pavlicova C. Jean Choi Tse‐Hwei Choo Jennifer M. Scodes Pamela Flood Kevin J. Tracey Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease clinical trial exercise training inflammation |
| title | Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults |
| title_full | Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults |
| title_fullStr | Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults |
| title_full_unstemmed | Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults |
| title_short | Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults |
| title_sort | aerobic exercise training and inducible inflammation results of a randomized controlled trial in healthy young adults |
| topic | clinical trial exercise training inflammation |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.010201 |
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