Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

Coagulation factor (F) Xa induces proinflammatory responses through activation of protease-activated receptors (PARs). However, the effect of FXa on cardiac fibroblasts (CFs) and the contribution of PARs in FXa-induced cellular signalling in CF has not been fully characterised. To answer these quest...

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Bibliographic Details
Main Authors: Elisa D’Alessandro, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, Frans A. van Nieuwenhoven
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
coagulation FXa
cardiac fibroblasts
inflammation
PARs
Online Access:https://www.mdpi.com/2073-4409/10/11/2958

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