Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis
Jiangfan Yu,1 Rui Tang,2 Ke Ding3 1Department of Dermatology, Second Xiangya Hospital of Central South University, Changsha, 410011, People’s Republic of China; 2Department of Rheumatology and Immunology, Second Xiangya Hospital of Central South University, Changsha, 410011, People’s Republic of Chi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-03-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/epigenetic-modifications-in-the-pathogenesis-of-systemic-sclerosis-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818445401886294016 |
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| author | Yu J Tang R Ding K |
| author_facet | Yu J Tang R Ding K |
| author_sort | Yu J |
| collection | DOAJ |
| description | Jiangfan Yu,1 Rui Tang,2 Ke Ding3 1Department of Dermatology, Second Xiangya Hospital of Central South University, Changsha, 410011, People’s Republic of China; 2Department of Rheumatology and Immunology, Second Xiangya Hospital of Central South University, Changsha, 410011, People’s Republic of China; 3Department of Urology, Xiangya Hospital of Central South University, Changsha, 410008, People’s Republic of ChinaCorrespondence: Ke Ding, Department of Urology, Xiangya Hospital of Central South University, Changsha, 410008, People’s Republic of China, Email dingke@csu.edu.cnAbstract: Systemic sclerosis is a rare chronic autoimmune disease, which mainly manifests as immune disorders, vascular damage, and progressive fibrosis. The etiology of SSc is complex and involves multiple factors. Both genetic and environmental factors are involved in its pathogenesis. As one of the molecular mechanisms of environmental factors, epigenetic regulation plays an important role in the occurrence and development of systemic sclerosis, which involves DNA methylation, histone modification and non-coding RNA regulation. This review summarizes research advances in epigenetics, including exosomes, lncRNA, and mentions possible biomarkers and therapeutic targets among them.Keywords: systemic sclerosis, pathogenesis, epigenetics, biomarkers |
| first_indexed | 2024-12-14T19:31:15Z |
| format | Article |
| id | doaj.art-ae3bcdf343a64bbd8c2e57d64b540283 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-14T19:31:15Z |
| publishDate | 2022-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-ae3bcdf343a64bbd8c2e57d64b5402832022-12-21T22:50:04ZengDove Medical PressInternational Journal of General Medicine1178-70742022-03-01Volume 153155316673804Epigenetic Modifications in the Pathogenesis of Systemic SclerosisYu JTang RDing KJiangfan Yu,1 Rui Tang,2 Ke Ding3 1Department of Dermatology, Second Xiangya Hospital of Central South University, Changsha, 410011, People’s Republic of China; 2Department of Rheumatology and Immunology, Second Xiangya Hospital of Central South University, Changsha, 410011, People’s Republic of China; 3Department of Urology, Xiangya Hospital of Central South University, Changsha, 410008, People’s Republic of ChinaCorrespondence: Ke Ding, Department of Urology, Xiangya Hospital of Central South University, Changsha, 410008, People’s Republic of China, Email dingke@csu.edu.cnAbstract: Systemic sclerosis is a rare chronic autoimmune disease, which mainly manifests as immune disorders, vascular damage, and progressive fibrosis. The etiology of SSc is complex and involves multiple factors. Both genetic and environmental factors are involved in its pathogenesis. As one of the molecular mechanisms of environmental factors, epigenetic regulation plays an important role in the occurrence and development of systemic sclerosis, which involves DNA methylation, histone modification and non-coding RNA regulation. This review summarizes research advances in epigenetics, including exosomes, lncRNA, and mentions possible biomarkers and therapeutic targets among them.Keywords: systemic sclerosis, pathogenesis, epigenetics, biomarkershttps://www.dovepress.com/epigenetic-modifications-in-the-pathogenesis-of-systemic-sclerosis-peer-reviewed-fulltext-article-IJGMsystemic sclerosispathogenesisepigeneticsbiomarkers. |
| spellingShingle | Yu J Tang R Ding K Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis International Journal of General Medicine systemic sclerosis pathogenesis epigenetics biomarkers. |
| title | Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis |
| title_full | Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis |
| title_fullStr | Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis |
| title_full_unstemmed | Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis |
| title_short | Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis |
| title_sort | epigenetic modifications in the pathogenesis of systemic sclerosis |
| topic | systemic sclerosis pathogenesis epigenetics biomarkers. |
| url | https://www.dovepress.com/epigenetic-modifications-in-the-pathogenesis-of-systemic-sclerosis-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT yuj epigeneticmodificationsinthepathogenesisofsystemicsclerosis AT tangr epigeneticmodificationsinthepathogenesisofsystemicsclerosis AT dingk epigeneticmodificationsinthepathogenesisofsystemicsclerosis |