The Cytoskeleton—A Complex Interacting Meshwork
The cytoskeleton of animal cells is one of the most complicated and functionally versatile structures, involved in processes such as endocytosis, cell division, intra-cellular transport, motility, force transmission, reaction to external forces, adhesion and preservation, and adaptation of cell shap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/4/362 |
| _version_ | 1797708281644318720 |
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| author | Tim Hohmann Faramarz Dehghani |
| author_facet | Tim Hohmann Faramarz Dehghani |
| author_sort | Tim Hohmann |
| collection | DOAJ |
| description | The cytoskeleton of animal cells is one of the most complicated and functionally versatile structures, involved in processes such as endocytosis, cell division, intra-cellular transport, motility, force transmission, reaction to external forces, adhesion and preservation, and adaptation of cell shape. These functions are mediated by three classical cytoskeletal filament types, as follows: Actin, microtubules, and intermediate filaments. The named filaments form a network that is highly structured and dynamic, responding to external and internal cues with a quick reorganization that is orchestrated on the time scale of minutes and has to be tightly regulated. Especially in brain tumors, the cytoskeleton plays an important role in spreading and migration of tumor cells. As the cytoskeletal organization and regulation is complex and many-faceted, this review aims to summarize the findings about cytoskeletal filament types, including substructures formed by them, such as lamellipodia, stress fibers, and interactions between intermediate filaments, microtubules and actin. Additionally, crucial regulatory aspects of the cytoskeletal filaments and the formed substructures are discussed and integrated into the concepts of cell motility. Even though little is known about the impact of cytoskeletal alterations on the progress of glioma, a final point discussed will be the impact of established cytoskeletal alterations in the cellular behavior and invasion of glioma. |
| first_indexed | 2024-03-12T06:20:07Z |
| format | Article |
| id | doaj.art-ae3bf302ee004b2386fd722a1625c4a2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:20:07Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ae3bf302ee004b2386fd722a1625c4a22023-09-03T02:19:02ZengMDPI AGCells2073-44092019-04-018436210.3390/cells8040362cells8040362The Cytoskeleton—A Complex Interacting MeshworkTim Hohmann0Faramarz Dehghani1Institute of Anatomy and Cell Biology, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse 52, 06108 Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse 52, 06108 Halle (Saale), GermanyThe cytoskeleton of animal cells is one of the most complicated and functionally versatile structures, involved in processes such as endocytosis, cell division, intra-cellular transport, motility, force transmission, reaction to external forces, adhesion and preservation, and adaptation of cell shape. These functions are mediated by three classical cytoskeletal filament types, as follows: Actin, microtubules, and intermediate filaments. The named filaments form a network that is highly structured and dynamic, responding to external and internal cues with a quick reorganization that is orchestrated on the time scale of minutes and has to be tightly regulated. Especially in brain tumors, the cytoskeleton plays an important role in spreading and migration of tumor cells. As the cytoskeletal organization and regulation is complex and many-faceted, this review aims to summarize the findings about cytoskeletal filament types, including substructures formed by them, such as lamellipodia, stress fibers, and interactions between intermediate filaments, microtubules and actin. Additionally, crucial regulatory aspects of the cytoskeletal filaments and the formed substructures are discussed and integrated into the concepts of cell motility. Even though little is known about the impact of cytoskeletal alterations on the progress of glioma, a final point discussed will be the impact of established cytoskeletal alterations in the cellular behavior and invasion of glioma.https://www.mdpi.com/2073-4409/8/4/362actinmicrotubulesintermediate filamentsmotilitymigrationgliomasignaling |
| spellingShingle | Tim Hohmann Faramarz Dehghani The Cytoskeleton—A Complex Interacting Meshwork Cells actin microtubules intermediate filaments motility migration glioma signaling |
| title | The Cytoskeleton—A Complex Interacting Meshwork |
| title_full | The Cytoskeleton—A Complex Interacting Meshwork |
| title_fullStr | The Cytoskeleton—A Complex Interacting Meshwork |
| title_full_unstemmed | The Cytoskeleton—A Complex Interacting Meshwork |
| title_short | The Cytoskeleton—A Complex Interacting Meshwork |
| title_sort | cytoskeleton a complex interacting meshwork |
| topic | actin microtubules intermediate filaments motility migration glioma signaling |
| url | https://www.mdpi.com/2073-4409/8/4/362 |
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