Reappraisal of oxidized HMGB1 as a mediator and biomarker

Reappraisal of oxidized HMGB1 as a mediator and biomarker

HMGB1 is a dual-function protein that acts as a chromatin-binding protein and as a danger-associated molecular pattern (DAMP) when released from activated immune cells or injured tissue. In much of the HMGB1 literature, immunomodulatory effects of extracellular HMGB1 are proposed to depend on its ox...

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Bibliographic Details
Main Authors: Ross Pirnie, Kevin P Gillespie, Clementina Mesaros, Ian A Blair
Format: Article
Language:English
Published: Future Science Ltd 2022-12-01
Series:Future Science OA
Subjects:
A-box. B-box
DAMP
DNA-binding
HMGB1
immune response
plasma biomarker
Online Access:https://www.future-science.com/doi/10.2144/fsoa-2022-0052

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