Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Abstract Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis. Over 70 mutations discovered in the GRN gene all result in reduced expression of the PGRN protein. Genetic and fu...

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Bibliographic Details
Main Authors: Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Neurodegeneration
Subjects:
Lysosome
Neuron
Progranulin
Proteomics
Half-life
Turnover
Online Access:https://doi.org/10.1186/s13024-023-00673-w

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