Human NK cells: From development to effector functions
NK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonot...
| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-04-01
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| Series: | Innate Immunity |
| Online Access: | https://doi.org/10.1177/17534259211001512 |
| _version_ | 1818655592609218560 |
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| author | Arosh Shavinda Perera Molligoda Arachchige |
| author_facet | Arosh Shavinda Perera Molligoda Arachchige |
| author_sort | Arosh Shavinda Perera Molligoda Arachchige |
| collection | DOAJ |
| description | NK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic granules, death receptor ligands, and cytokines to perform their effector functions. In this review, we provide a general overview of human NK cells, as opposed to murine NK cells, discussing their ontogeny, maturation, receptor diversity, types of responses, and effector functions. Furthermore, we also describe recent advances in human NK cell biology, including tissue-resident NK cell populations, NK cell memory, and novel approaches used to target NK cells in cancer immunotherapy. |
| first_indexed | 2024-12-17T03:12:09Z |
| format | Article |
| id | doaj.art-ae41c43f29b34bb9a02b060e012fb987 |
| institution | Directory Open Access Journal |
| issn | 1753-4259 1753-4267 |
| language | English |
| last_indexed | 2024-12-17T03:12:09Z |
| publishDate | 2021-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Innate Immunity |
| spelling | doaj.art-ae41c43f29b34bb9a02b060e012fb9872022-12-21T22:05:48ZengSAGE PublishingInnate Immunity1753-42591753-42672021-04-012710.1177/17534259211001512Human NK cells: From development to effector functionsArosh Shavinda Perera Molligoda ArachchigeNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic granules, death receptor ligands, and cytokines to perform their effector functions. In this review, we provide a general overview of human NK cells, as opposed to murine NK cells, discussing their ontogeny, maturation, receptor diversity, types of responses, and effector functions. Furthermore, we also describe recent advances in human NK cell biology, including tissue-resident NK cell populations, NK cell memory, and novel approaches used to target NK cells in cancer immunotherapy.https://doi.org/10.1177/17534259211001512 |
| spellingShingle | Arosh Shavinda Perera Molligoda Arachchige Human NK cells: From development to effector functions Innate Immunity |
| title | Human NK cells: From development to effector functions |
| title_full | Human NK cells: From development to effector functions |
| title_fullStr | Human NK cells: From development to effector functions |
| title_full_unstemmed | Human NK cells: From development to effector functions |
| title_short | Human NK cells: From development to effector functions |
| title_sort | human nk cells from development to effector functions |
| url | https://doi.org/10.1177/17534259211001512 |
| work_keys_str_mv | AT aroshshavindapereramolligodaarachchige humannkcellsfromdevelopmenttoeffectorfunctions |