Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses

Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses

In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) and 2-oxoadipate (OADH, encoded by DHTKD1), respectively. To assess the selectivity in animals, the effects of SP, AP, and their mem...

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Bibliographic Details
Main Authors: Victoria I. Bunik, Artem V. Artiukhov, Alexey V. Kazantsev, Vasily A. Aleshin, Alexandra I. Boyko, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Chemistry
Subjects:
2-oxoglutarate dehydrogenase
2-oxoadipate dehydrogenase
DHTKD1
phosphonate analog of 2-oxo acid
regulation of brain metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.892284/full

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