Persistent immune activation and altered gut integrity over time in a longitudinal study of Ugandan youth with perinatally acquired HIV

Persistent immune activation and altered gut integrity over time in a longitudinal study of Ugandan youth with perinatally acquired HIV

IntroductionPerinatally acquired HIV infection (PHIV) occurs during a critical window of immune development. We investigated changes in systemic inflammation and immune activation in adolescents with PHIV and those without HIV (HIV-) in Uganda.MethodsA prospective observational cohort study was perf...

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Bibliographic Details
Main Authors: Sahera Dirajlal-Fargo, Monika Strah, Kate Ailstock, Abdus Sattar, Christine Karungi, Rashidah Nazzinda, Cissy Kityo, Victor Musiime, Nicholas Funderburg, Grace A. McComsey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
inflammation
immune activation
gut integrity
microbial translocation
children
HIV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165964/full

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