Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-023-03079-z |
| _version_ | 1827710662379307008 |
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| author | Sangeetha Shyam Jesús Francisco García-Gavilán Indira Paz-Graniel José J. Gaforio Miguel Ángel Martínez-González Dolores Corella J. Alfredo Martínez Ángel M. Alonso-Gómez Julia Wärnberg Jesús Vioque Dora Romaguera José López-Miranda Ramon Estruch Francisco J. Tinahones José Lapetra J. Luís Serra-Majem Aurora Bueno-Cavanillas Josep A. Tur Vicente Martín Sánchez Xavier Pintó Pilar Matía-Martín Josep Vidal Clotilde Vázquez Lidia Daimiel Emilio Ros Fernando Fernandez-Aranda Stephanie K. Nishi Oscar Garcia-Regata Estefania Toledo Eva M. Asensio Olga Castañer Antonio Garcia-Rios Laura Torres-Collado Enrique Gómez-Gracia M. Angeles Zulet Nuria Goñi Ruiz Rosa Casas Naomi Cano-Ibáñez Lucas Tojal-Sierra A. M. Gómez-Perez Jose V. Sorlí Sergio Cinza-Sanjurjo Sandra Martín-Peláez Patricia J. Peña-Orihuela Alejandro Oncina-Canovas Rafael Perez-Araluce María Dolores Zomeño Alice Chaplin Miguel Delgado-Rodríguez Nancy Babio Montserrat Fitó Jordi Salas-Salvadó |
| author_facet | Sangeetha Shyam Jesús Francisco García-Gavilán Indira Paz-Graniel José J. Gaforio Miguel Ángel Martínez-González Dolores Corella J. Alfredo Martínez Ángel M. Alonso-Gómez Julia Wärnberg Jesús Vioque Dora Romaguera José López-Miranda Ramon Estruch Francisco J. Tinahones José Lapetra J. Luís Serra-Majem Aurora Bueno-Cavanillas Josep A. Tur Vicente Martín Sánchez Xavier Pintó Pilar Matía-Martín Josep Vidal Clotilde Vázquez Lidia Daimiel Emilio Ros Fernando Fernandez-Aranda Stephanie K. Nishi Oscar Garcia-Regata Estefania Toledo Eva M. Asensio Olga Castañer Antonio Garcia-Rios Laura Torres-Collado Enrique Gómez-Gracia M. Angeles Zulet Nuria Goñi Ruiz Rosa Casas Naomi Cano-Ibáñez Lucas Tojal-Sierra A. M. Gómez-Perez Jose V. Sorlí Sergio Cinza-Sanjurjo Sandra Martín-Peláez Patricia J. Peña-Orihuela Alejandro Oncina-Canovas Rafael Perez-Araluce María Dolores Zomeño Alice Chaplin Miguel Delgado-Rodríguez Nancy Babio Montserrat Fitó Jordi Salas-Salvadó |
| author_sort | Sangeetha Shyam |
| collection | DOAJ |
| description | Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ). |
| first_indexed | 2024-03-10T17:41:59Z |
| format | Article |
| id | doaj.art-ae441de407a3493ea241c36df6ae0610 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-03-10T17:41:59Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-ae441de407a3493ea241c36df6ae06102023-11-20T09:40:58ZengBMCBMC Medicine1741-70152023-10-0121111310.1186/s12916-023-03079-zAssociation of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohortSangeetha Shyam0Jesús Francisco García-Gavilán1Indira Paz-Graniel2José J. Gaforio3Miguel Ángel Martínez-González4Dolores Corella5J. Alfredo Martínez6Ángel M. Alonso-Gómez7Julia Wärnberg8Jesús Vioque9Dora Romaguera10José López-Miranda11Ramon Estruch12Francisco J. Tinahones13José Lapetra14J. Luís Serra-Majem15Aurora Bueno-Cavanillas16Josep A. Tur17Vicente Martín Sánchez18Xavier Pintó19Pilar Matía-Martín20Josep Vidal21Clotilde Vázquez22Lidia Daimiel23Emilio Ros24Fernando Fernandez-Aranda25Stephanie K. Nishi26Oscar Garcia-Regata27Estefania Toledo28Eva M. Asensio29Olga Castañer30Antonio Garcia-Rios31Laura Torres-Collado32Enrique Gómez-Gracia33M. Angeles Zulet34Nuria Goñi Ruiz35Rosa Casas36Naomi Cano-Ibáñez37Lucas Tojal-Sierra38A. M. Gómez-Perez39Jose V. Sorlí40Sergio Cinza-Sanjurjo41Sandra Martín-Peláez42Patricia J. Peña-Orihuela43Alejandro Oncina-Canovas44Rafael Perez-Araluce45María Dolores Zomeño46Alice Chaplin47Miguel Delgado-Rodríguez48Nancy Babio49Montserrat Fitó50Jordi Salas-Salvadó51Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIIDepartment of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC)CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIIBioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHUCentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Departament of Preventive Medicine, University of MálagaCentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIIServicio Navarro de Salud-OsasumbideaCentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICS MilladoiroÁrea Sanitaria de Santiago de CompostelaCIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII)Department of Preventive Medicine and Public Health, Instituto de Investigación Sanitaria de Navarra (IdiSNA), University of NavarraCentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de La Obesidad y La Nutrición (CIBEROBN), Institute of Health Carlos IIIAbstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).https://doi.org/10.1186/s12916-023-03079-zObesityCOVID-19Older adultsWeight lossCentral obesity |
| spellingShingle | Sangeetha Shyam Jesús Francisco García-Gavilán Indira Paz-Graniel José J. Gaforio Miguel Ángel Martínez-González Dolores Corella J. Alfredo Martínez Ángel M. Alonso-Gómez Julia Wärnberg Jesús Vioque Dora Romaguera José López-Miranda Ramon Estruch Francisco J. Tinahones José Lapetra J. Luís Serra-Majem Aurora Bueno-Cavanillas Josep A. Tur Vicente Martín Sánchez Xavier Pintó Pilar Matía-Martín Josep Vidal Clotilde Vázquez Lidia Daimiel Emilio Ros Fernando Fernandez-Aranda Stephanie K. Nishi Oscar Garcia-Regata Estefania Toledo Eva M. Asensio Olga Castañer Antonio Garcia-Rios Laura Torres-Collado Enrique Gómez-Gracia M. Angeles Zulet Nuria Goñi Ruiz Rosa Casas Naomi Cano-Ibáñez Lucas Tojal-Sierra A. M. Gómez-Perez Jose V. Sorlí Sergio Cinza-Sanjurjo Sandra Martín-Peláez Patricia J. Peña-Orihuela Alejandro Oncina-Canovas Rafael Perez-Araluce María Dolores Zomeño Alice Chaplin Miguel Delgado-Rodríguez Nancy Babio Montserrat Fitó Jordi Salas-Salvadó Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort BMC Medicine Obesity COVID-19 Older adults Weight loss Central obesity |
| title | Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort |
| title_full | Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort |
| title_fullStr | Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort |
| title_full_unstemmed | Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort |
| title_short | Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort |
| title_sort | association of adiposity and its changes over time with covid 19 risk in older adults with overweight obesity and metabolic syndrome a longitudinal evaluation in the predimed plus cohort |
| topic | Obesity COVID-19 Older adults Weight loss Central obesity |
| url | https://doi.org/10.1186/s12916-023-03079-z |
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