Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream
This study investigated the effect of flavoured nanophytosomes loaded with vitamins A, E, D, B complex, folic acid, and C, as well as zinc on the immunosuppressive cyclosporin A (CsA)-induced liver and kidney injury in male rats. The vitamins flavoured nanophytosomes (VFnPs) were characterized in te...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023111029 |
| _version_ | 1797336911075868672 |
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| author | Manal M. Ramadan Rasha S. Mohamed Amal G. Hussien Ola A.M. Mohawed Ahmed M. Mabrouk Abeer E. Mahmoud Kadry Z. Ghanem Tamer M. El-Messery |
| author_facet | Manal M. Ramadan Rasha S. Mohamed Amal G. Hussien Ola A.M. Mohawed Ahmed M. Mabrouk Abeer E. Mahmoud Kadry Z. Ghanem Tamer M. El-Messery |
| author_sort | Manal M. Ramadan |
| collection | DOAJ |
| description | This study investigated the effect of flavoured nanophytosomes loaded with vitamins A, E, D, B complex, folic acid, and C, as well as zinc on the immunosuppressive cyclosporin A (CsA)-induced liver and kidney injury in male rats. The vitamins flavoured nanophytosomes (VFnPs) were characterized in terms of particle size, zeta potential, encapsulation efficiency. Ice cream was flavoured with star anise volatile oil to mask the VFnPs' flavour and unacceptable taste. The study found that treatment with CsA alone resulted in increased (P > 0.05) levels of creatinine, urea, and MDA, as well as the activities of AST and ALT, while the levels of SOD, CAT, GST, proteins, CD4, INF-ᵧ, IL-6, IL-1β, and TLR4 decreased (P > 0.05). However, the group that received CsA simultaneously with VFnPs showed a significant (P > 0.05) decrease in the levels of creatinine, urea, and MDA, as well as the activities of AST and ALT, and increased (P > 0.05) levels of SOD, CAT, GST, proteins, CD4, INF-ᵧ, IL-6, IL-1β, and TLR4. The increase in the ratio of VFnPs had little effect on the physiochemical and sensory evaluation of the ice cream. Finally, the study suggests that VFnPs could potentially protect against CsA-induced liver and kidney injury and serve as a promising natural therapy for treating such conditions. |
| first_indexed | 2024-03-08T09:01:46Z |
| format | Article |
| id | doaj.art-ae4448810f7f49cd8492045cb58e802b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:01:46Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ae4448810f7f49cd8492045cb58e802b2024-02-01T06:34:01ZengElsevierHeliyon2405-84402024-01-01101e23894Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice creamManal M. Ramadan0Rasha S. Mohamed1Amal G. Hussien2Ola A.M. Mohawed3Ahmed M. Mabrouk4Abeer E. Mahmoud5Kadry Z. Ghanem6Tamer M. El-Messery7Chemistry of Flavour and Aroma Department, National Research Centre, Cairo, EgyptNutrition and Food Sciences Department, National Research Centre, Cairo, EgyptBiochemistry Department, Biotechnology Research Institute, National Research Centre. Cairo, EgyptHormones Department, Medical Research and Clinical Studies Institute, National Research Centre. Cairo, EgyptDairy Science Department, National Research Centre, Cairo, EgyptBiochemistry Department, Biotechnology Research Institute, National Research Centre. Cairo, EgyptNutrition and Food Sciences Department, National Research Centre, Cairo, EgyptInternational Research Centre “Biotechnologies of the Third Millennium”, Faculty of Biotechnologies (BioTech), ITMO University, St. Petersburg, 191002, Russia; Corresponding author.This study investigated the effect of flavoured nanophytosomes loaded with vitamins A, E, D, B complex, folic acid, and C, as well as zinc on the immunosuppressive cyclosporin A (CsA)-induced liver and kidney injury in male rats. The vitamins flavoured nanophytosomes (VFnPs) were characterized in terms of particle size, zeta potential, encapsulation efficiency. Ice cream was flavoured with star anise volatile oil to mask the VFnPs' flavour and unacceptable taste. The study found that treatment with CsA alone resulted in increased (P > 0.05) levels of creatinine, urea, and MDA, as well as the activities of AST and ALT, while the levels of SOD, CAT, GST, proteins, CD4, INF-ᵧ, IL-6, IL-1β, and TLR4 decreased (P > 0.05). However, the group that received CsA simultaneously with VFnPs showed a significant (P > 0.05) decrease in the levels of creatinine, urea, and MDA, as well as the activities of AST and ALT, and increased (P > 0.05) levels of SOD, CAT, GST, proteins, CD4, INF-ᵧ, IL-6, IL-1β, and TLR4. The increase in the ratio of VFnPs had little effect on the physiochemical and sensory evaluation of the ice cream. Finally, the study suggests that VFnPs could potentially protect against CsA-induced liver and kidney injury and serve as a promising natural therapy for treating such conditions.http://www.sciencedirect.com/science/article/pii/S2405844023111029Flavoured nanophytosomeVitaminsImmune systemStar aniseIce creamPhytosome encapsulation |
| spellingShingle | Manal M. Ramadan Rasha S. Mohamed Amal G. Hussien Ola A.M. Mohawed Ahmed M. Mabrouk Abeer E. Mahmoud Kadry Z. Ghanem Tamer M. El-Messery Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream Heliyon Flavoured nanophytosome Vitamins Immune system Star anise Ice cream Phytosome encapsulation |
| title | Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream |
| title_full | Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream |
| title_fullStr | Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream |
| title_full_unstemmed | Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream |
| title_short | Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream |
| title_sort | ameliorative effects of vitamins loaded flavoured nanophytosomes fortified with star anise volatile oil against csa induced liver and kidney injury in rats application in functional ice cream |
| topic | Flavoured nanophytosome Vitamins Immune system Star anise Ice cream Phytosome encapsulation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023111029 |
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