Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide
Wegener’s granulomatosis or granulomatosis polyangiitis associated (GPA) is a granulomatous inflammation of the upper and lower respiratory tracts associated with necrotising vasculitis of small and medium-sized blood vessels and, frequently, necrotising glomerulonephritis. We describe the case of a...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2013-05-01
|
| Series: | Reumatismo |
| Subjects: | |
| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/645 |
| _version_ | 1818246821099601920 |
|---|---|
| author | M. Benucci F. Li Gobbi P. Panconesi M. Manfredi P. Sarzi-Puttini F. Atzeni |
| author_facet | M. Benucci F. Li Gobbi P. Panconesi M. Manfredi P. Sarzi-Puttini F. Atzeni |
| author_sort | M. Benucci |
| collection | DOAJ |
| description | Wegener’s granulomatosis or granulomatosis polyangiitis associated (GPA) is a granulomatous inflammation of the upper and lower respiratory tracts associated with necrotising vasculitis of small and medium-sized blood vessels and, frequently, necrotising glomerulonephritis. We describe the case of a 37 year old female patient presenting with upper respiratory tract involvement, chronic rhinosinusitis with green secretions, and bilateral hypoacusia. Ten months later, she suffered occipital headache and two episodes of lipothymia associated with nausea, photophobia, faintness with visual blurring. Magnetic resonance imaging (MRI) revealed aseptic meningitis. The patient was treated with steroids and cyclophosphamide without any effect on the neurological symptoms which, however, greatly improved after subsequent treatment with rituximab as confirmed by means of cerebral MRI. Rituximab is an optimal means of treating cyclophosphamide-resistant patients with GPA associated with meningeal involvement. |
| first_indexed | 2024-12-12T14:54:54Z |
| format | Article |
| id | doaj.art-ae4467b1f3b74bdeb60aa9ee1af4d723 |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-12-12T14:54:54Z |
| publishDate | 2013-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-ae4467b1f3b74bdeb60aa9ee1af4d7232022-12-22T00:20:56ZengPAGEPress PublicationsReumatismo0048-74492240-26832013-05-01652909410.4081/reumatismo.2013.90602Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamideM. Benucci0F. Li Gobbi1P. Panconesi2M. Manfredi3P. Sarzi-Puttini4F. Atzeni5Rheumatology Unit, San Giovanni di Dio Hospital, FlorenceRheumatology Unit, San Giovanni di Dio Hospital, FlorenceRadiology Unit, San Giovanni di Dio Hospital, FlorenceImmunology and Allergology Laboratory, San Giovanni di Dio Hospital, FlorenceRheumatology Unit, L. Sacco University Hospital, MilanRheumatology Unit, L. Sacco University Hospital, MilanWegener’s granulomatosis or granulomatosis polyangiitis associated (GPA) is a granulomatous inflammation of the upper and lower respiratory tracts associated with necrotising vasculitis of small and medium-sized blood vessels and, frequently, necrotising glomerulonephritis. We describe the case of a 37 year old female patient presenting with upper respiratory tract involvement, chronic rhinosinusitis with green secretions, and bilateral hypoacusia. Ten months later, she suffered occipital headache and two episodes of lipothymia associated with nausea, photophobia, faintness with visual blurring. Magnetic resonance imaging (MRI) revealed aseptic meningitis. The patient was treated with steroids and cyclophosphamide without any effect on the neurological symptoms which, however, greatly improved after subsequent treatment with rituximab as confirmed by means of cerebral MRI. Rituximab is an optimal means of treating cyclophosphamide-resistant patients with GPA associated with meningeal involvement.http://www.reumatismo.org/index.php/reuma/article/view/645Granulomatosis polyangiitis associated, Rituximab |
| spellingShingle | M. Benucci F. Li Gobbi P. Panconesi M. Manfredi P. Sarzi-Puttini F. Atzeni Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide Reumatismo Granulomatosis polyangiitis associated, Rituximab |
| title | Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide |
| title_full | Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide |
| title_fullStr | Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide |
| title_full_unstemmed | Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide |
| title_short | Granulomatosis polyangiitis associated with meningeal involvement: response to rituximab therapy after failure of cyclophosphamide |
| title_sort | granulomatosis polyangiitis associated with meningeal involvement response to rituximab therapy after failure of cyclophosphamide |
| topic | Granulomatosis polyangiitis associated, Rituximab |
| url | http://www.reumatismo.org/index.php/reuma/article/view/645 |
| work_keys_str_mv | AT mbenucci granulomatosispolyangiitisassociatedwithmeningealinvolvementresponsetorituximabtherapyafterfailureofcyclophosphamide AT fligobbi granulomatosispolyangiitisassociatedwithmeningealinvolvementresponsetorituximabtherapyafterfailureofcyclophosphamide AT ppanconesi granulomatosispolyangiitisassociatedwithmeningealinvolvementresponsetorituximabtherapyafterfailureofcyclophosphamide AT mmanfredi granulomatosispolyangiitisassociatedwithmeningealinvolvementresponsetorituximabtherapyafterfailureofcyclophosphamide AT psarziputtini granulomatosispolyangiitisassociatedwithmeningealinvolvementresponsetorituximabtherapyafterfailureofcyclophosphamide AT fatzeni granulomatosispolyangiitisassociatedwithmeningealinvolvementresponsetorituximabtherapyafterfailureofcyclophosphamide |