High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort
Introduction: Presence of chronic low grade inflammation has often been implicated in the etiology of atrial fibrillation (AF). Whether pre-existing inflammatory state promotes AF or initiation of AF activates inflammation is a dilemma among clinicians. This study investigates the role of high sensi...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Indian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483216309816 |
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| author | Gautam Sharma Sudhir Shetkar Ashu Bhasin Lakshmy Ramakrishnan Rajnish Juneja Nitish Naik Ambuj Roy Sivasubramanian Ramakrishnan Balram Bhargava Vinay Kumar Bahl |
| author_facet | Gautam Sharma Sudhir Shetkar Ashu Bhasin Lakshmy Ramakrishnan Rajnish Juneja Nitish Naik Ambuj Roy Sivasubramanian Ramakrishnan Balram Bhargava Vinay Kumar Bahl |
| author_sort | Gautam Sharma |
| collection | DOAJ |
| description | Introduction: Presence of chronic low grade inflammation has often been implicated in the etiology of atrial fibrillation (AF). Whether pre-existing inflammatory state promotes AF or initiation of AF activates inflammation is a dilemma among clinicians. This study investigates the role of high sensitive C reactive protein (hs-CRP) and interleukin 6 (IL-6) in AF with rheumatic mitral stenosis (Rh-MS) as markers of chronic inflammation.
Methods: This case control cohort included sixty five (n = 65) Rh-MS patients having other valve lesions as trivial to mild. Out of them twenty nine (n = 29; group C) had baseline AF and rest were normal sinus rhythm (NSR). A 24 h holter recording was done in NSR patients to diagnose paroxysmal AF/tachyarrhythmia forming group B (n = 12) and not having any tachyarrhythmia were designated as NSR; group A (n = 24).
Results: hs-CRP and IL6 showed statistically significant increase in group C (permanent AF) compared to group A (95% CI: 4.2–0.9, p = 0.007; 95% CI: 1.2–0.89; p = 0.05 respectively), while it was non significant between group A and group B (p > 0.05). A weak positive correlation was observed with hs-CRP and left atrial volume index (LAVi) (r = 0.45, p = 0.06) in AF group as compared to NSR group. 68.2% of patients in AF group (27/41) had moderate to severe spontaneous echo contrast (SEC) as compared to 37.5% (10/24) in NSR group.
Conclusion: Increased hs-CRP and IL-6 levels in the paroxysmal and permanent AF group may favour the hypothesis that low grade chronic inflammation could be the cause of atrial fibrillation than a consequence. |
| first_indexed | 2024-12-20T22:22:49Z |
| format | Article |
| id | doaj.art-ae4485b0e3064d2891a53a7530e62177 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-20T22:22:49Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-ae4485b0e3064d2891a53a7530e621772022-12-21T19:24:53ZengElsevierIndian Heart Journal0019-48322017-07-0169450551110.1016/j.ihj.2016.12.006High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohortGautam Sharma0Sudhir Shetkar1Ashu Bhasin2Lakshmy Ramakrishnan3Rajnish Juneja4Nitish Naik5Ambuj Roy6Sivasubramanian Ramakrishnan7Balram Bhargava8Vinay Kumar Bahl9Department of Cardiology, Room No 12, 8th floor, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, Apollo Group of Hospitals, Nashik, IndiaDepartment of Neurology, All India Institute of Medical Sciences, Room No 708, New Delhi, IndiaDepartment of Cardiac Biochemistry, All India Institute of Medical Sciences, Room No 61 Ground Floor, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, IndiaIntroduction: Presence of chronic low grade inflammation has often been implicated in the etiology of atrial fibrillation (AF). Whether pre-existing inflammatory state promotes AF or initiation of AF activates inflammation is a dilemma among clinicians. This study investigates the role of high sensitive C reactive protein (hs-CRP) and interleukin 6 (IL-6) in AF with rheumatic mitral stenosis (Rh-MS) as markers of chronic inflammation. Methods: This case control cohort included sixty five (n = 65) Rh-MS patients having other valve lesions as trivial to mild. Out of them twenty nine (n = 29; group C) had baseline AF and rest were normal sinus rhythm (NSR). A 24 h holter recording was done in NSR patients to diagnose paroxysmal AF/tachyarrhythmia forming group B (n = 12) and not having any tachyarrhythmia were designated as NSR; group A (n = 24). Results: hs-CRP and IL6 showed statistically significant increase in group C (permanent AF) compared to group A (95% CI: 4.2–0.9, p = 0.007; 95% CI: 1.2–0.89; p = 0.05 respectively), while it was non significant between group A and group B (p > 0.05). A weak positive correlation was observed with hs-CRP and left atrial volume index (LAVi) (r = 0.45, p = 0.06) in AF group as compared to NSR group. 68.2% of patients in AF group (27/41) had moderate to severe spontaneous echo contrast (SEC) as compared to 37.5% (10/24) in NSR group. Conclusion: Increased hs-CRP and IL-6 levels in the paroxysmal and permanent AF group may favour the hypothesis that low grade chronic inflammation could be the cause of atrial fibrillation than a consequence.http://www.sciencedirect.com/science/article/pii/S0019483216309816Rheumatic mitral stenosisAtrial fibrillationHs-CRP & IL6 |
| spellingShingle | Gautam Sharma Sudhir Shetkar Ashu Bhasin Lakshmy Ramakrishnan Rajnish Juneja Nitish Naik Ambuj Roy Sivasubramanian Ramakrishnan Balram Bhargava Vinay Kumar Bahl High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort Indian Heart Journal Rheumatic mitral stenosis Atrial fibrillation Hs-CRP & IL6 |
| title | High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort |
| title_full | High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort |
| title_fullStr | High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort |
| title_full_unstemmed | High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort |
| title_short | High sensitive C-reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from Indian cohort |
| title_sort | high sensitive c reactive protein and interleukin 6 in atrial fibrillation with rheumatic mitral stenosis from indian cohort |
| topic | Rheumatic mitral stenosis Atrial fibrillation Hs-CRP & IL6 |
| url | http://www.sciencedirect.com/science/article/pii/S0019483216309816 |
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